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EDEM2 Antibody

  • 货号：
    CSB-PA030228
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9BV94
  • 基因名：
  • 别名：
    bA4204.1 antibody; C20orf31 antibody; C20orf49 antibody; EDEM 2 antibody; EDEM2 antibody; EDEM2_HUMAN antibody; ER degradation enhancer mannosidase alpha like 2 antibody; ER degradation enhancing alpha mannosidase like 2 antibody; ER degradation enhancing alpha mannosidase like protein 2 antibody; ER degradation enhancing mannosidase like protein 2 antibody; ER degradation-enhancing alpha-mannosidase-like 2 antibody; FLJ10783 antibody; UNQ573/PRO1135 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human EDEM2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins.
  • 基因功能参考文献：
    1. EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog PMID: 24910992
    2. Glycoproteins mannose trimming from Man9GlcNAc2 to Man8GlcNAc2 is conducted mainly by EDEM2. PMID: 25092655
    3. Overexpression of EDEM2 accelerates the degradation of misfolded alpha1-antitrypsin, indicating that the protein is involved in endoplasmic reticulum associated degradation. PMID: 15537790
    4. EDEM2 regulates endoplasmic reticulum-associated glycoprotein degradation PMID: 15579471
    5. Degrades misfolded alpha1-antitrypsin in the ER. PMID: 15537790

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  • 亚细胞定位：
    Endoplasmic reticulum lumen.
  • 蛋白家族：
    Glycosyl hydrolase 47 family
  • 组织特异性：
    Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle.
  • 数据库链接：

    HGNC: 15877

    OMIM: 610302

    KEGG: hsa:55741

    STRING: 9606.ENSP00000363616

    UniGene: Hs.720177