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  4. DUSP22 Antibody

DUSP22 Antibody

  • 货号：
    CSB-PA181246
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA181246(DUSP22 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9NRW4
  • 基因名：
    DUSP22
  • 别名：
    Dual specificity protein phosphatase 22 antibody; DUS22_HUMAN antibody; Dusp22 antibody; JNK stimulatory phosphatase 1 antibody; JNK-stimulatory phosphatase-1 antibody; JSP 1 antibody; JSP-1 antibody; JSP1 antibody; LMW DSP2 antibody; LMW-DSP2 antibody; Low molecular weight dual specificity phosphatase 2 antibody; MAP kinase phosphatase x antibody; Mitogen activated protein kinase phosphatase x antibody; Mitogen-activated protein kinase phosphatase x antibody; MKP-x antibody; MKPX antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human DUSP22
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Activates the Jnk signaling pathway.
  • 基因功能参考文献：
    1. JKAP/DUSP22 is downregulated in T cells of systemic lupus erythematosus nephritis PMID: 27557500
    2. Data show that dual specificity phosphatase 22 (DUSP22) functions as a tumor suppressor gene in peripheral T-cell lymphomas (PTCL). PMID: 27626696
    3. findings connect NOTCH1, DUSP22, and CCL19-driven chemotaxis within a single functional network, suggesting that modulation of the homing process may provide a relevant contribution to the unfavorable prognosis associated with NOTCH1 mutations in CLL. PMID: 28017968
    4. findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease PMID: 25390351
    5. Studies suggest that the presence of dual specificity phosphatase 22 (DUSP22) and p63 tumor suppressor protein (TP63) rearrangements might be useful to support a diagnosis of anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL). PMID: 26223379
    6. Report morphologic features of ALK-negative anaplastic large cell lymphomas with DUSP22 gene rearrangements. PMID: 26379151
    7. Reduced DUSP22 expression was found in colorectal cancer specimens. Low expression level of DUSP22 in stage IV patients had a poor survival outcome PMID: 26032091
    8. The structure illuminates the molecular basis for substrate binding and may also facilitate the structure-assisted development of DUSP22 inhibitors. PMID: 25664796
    9. study identified presence of promoter hypermethylation of the DUSP22 gene in Alzheimer's disease(AD); DUSP22 is a likely candidate gene for involvement in the pathogenesis of AD since it inhibits PKA activity and thereby determines TAU phosphorylation status and CREB signaling PMID: 24436131
    10. Biallelic rearrangements of DUSP22 is found in CD30-positive T-cell lymphoproliferative disorders. PMID: 23337887
    11. Firefighters had a higher prevalence of dual specificity phosphatase 22-promoter hypomethylation in blood DNA (P = 0.03) and the extent of hypomethylation correlated with duration of firefighting service (P = 0.04) but not with age. PMID: 22796920
    12. Data show that t(6;7)(p25.3;q32.3) was associated with down-regulation of DUSP22 and up-regulation of MIR29 microRNAs on 7q32.3. PMID: 21030553
    13. a new role for JKAP in the modulation of FAK phosphorylation and cell motility. PMID: 20018849
    14. The crystal structre showed 1 domain with 6 alpha helices & 5 beta strans, a PTP-loop at the active site binding MES, and an Ala instead of a Trp at the substrate-stacking loop. PMID: 17068812
    15. DUSP22 acts as a negative regulator of the estrogen receptor alpha-mediated signaling pathway in breast cancer cells. PMID: 17384676

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 组织特异性：
    Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas.
  • 数据库链接：

    HGNC: 16077

    KEGG: hsa:56940

    STRING: 9606.ENSP00000345281

    UniGene: Hs.29106