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  4. DOC2B Antibody

DOC2B Antibody

  • 货号：
    CSB-PA007092GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q14184
  • 基因名：
    DOC2B
  • 别名：
    Doc2 beta antibody; Doc2-beta antibody; Doc2b antibody; DOC2B_HUMAN antibody; DOC2BL antibody; Double C2 like domain containing protein beta antibody; Double C2 like domains beta antibody; Double C2 like domains beta like antibody; Double C2-like domain-containing protein beta antibody; OTTMUSP00000006522 antibody; RP23 78H4.2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DOC2B
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.
  • 基因功能参考文献：
    1. Reduction of DOC2B is an early feature of T1 diabetes (T1D), and DOC2B abundance may serve as a valuable in vivo indicator of beta-cell mass and an early biomarker of T1D. PMID: 29506054
    2. Here the s report that analogous ring-like oligomers assemble from the C2AB domains of other Syt isoforms (Syt2, Syt7, Syt9) as well as related C2 domain containing protein, Doc2B and extended Synaptotagmins (E-Syts). PMID: 27434670
    3. promoter hypermethylation and silencing of the DOC2B gene is an early and frequent event during cervical carcinogenesis and whose reduced expression due to DNA promoter methylation may lead to selective cervical tumor growth PMID: 24570007
    4. Study analyzed Doc2alpha and Doc2beta and found that Doc2 responds to changes in [Ca2+], with markedly slower kinetics as compared to the cytosolic domain of syt I (syt), and operates on a timescale consistent with asynchronous neurotransmitter release. PMID: 22036572
  • 亚细胞定位：
    Cytoplasm. Cytoplasmic granule. Cell membrane; Peripheral membrane protein.
  • 组织特异性：
    Widely expressed with highest levels in brain and kidney. Expressed in pancreatic islet cells (at protein level).
  • 数据库链接：

    HGNC: 2986

    OMIM: 604568

    KEGG: hsa:8447

    STRING: 9606.ENSP00000343665

    UniGene: Hs.551705