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DMC1 Antibody

  • 货号：
    CSB-PA006781
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q14565
  • 基因名：
    DMC1
  • 别名：
    Disrupted meiotic cDNA 1 homolog antibody; Disrupted meiotic cDNA 1; yeast; homolog of antibody; dJ199H16.1 antibody; DMC 1 antibody; DMC1 antibody; DMC1 dosage suppressor of mck1 homolog antibody; DMC1 dosage suppressor of mck1 homolog meiosis specific homologous recombination (yeast) antibody; DMC1 homologue antibody; DMC1_HUMAN antibody; DMC1H antibody; DNA meiotic recombinase 1 antibody; HsLim15 antibody; LIM15 antibody; Meiotic recombination protein DMC1/LIM15 homolog antibody; MGC150472 antibody; MGC150473 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Dmc1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
  • 基因功能参考文献：
    1. Data indicate that ahomologous pairing by DMC1 protein or RAD51 recombinase in chromatin containing nucleosome-depleted double-stranded DNA (dsDNA) regions. PMID: 27052786
    2. BRCA2 protein stimulates DMC1-mediated DNA strand exchange between RPA-ssDNA complexes and duplex DNA, thus identifying BRCA2 as a mediator of DMC1 recombination function. PMID: 26976601
    3. Dmc1 can reject divergent DNA sequences while bypassing a few mismatches in the DNA sequence. PMID: 26709229
    4. In contrast to RAD51, stabilization of the presynaptic filament via ATP hydrolysis attenuation is insufficient for enhancement of the DMC1-catalyzed recombination reaction. PMID: 26088134
    5. truncated DMC1 octamers further stack with alternate polarity into a filament PMID: 23545642
    6. results suggested mutations in the coding sequence of DMC1 are not associated with premature ovarian failure in Chinese women PMID: 23265958
    7. conserved lysine in the Walker A motif of hDMC1 is critical for ATP binding. PMID: 23182424
    8. The results suggested that PSF may function as an activator for the meiosis-specific recombinase DMC1. PMID: 22156371
    9. D-loops in a human DMC1-driven reaction are substantially more resistant to dissociation by branch-migration proteins such as RAD54 than those formed by RAD51. PMID: 21151113
    10. the Dmc1 filament formed on single-stranded DNA has a mass per unit length expected from approximately 6.5 subunits per turn PMID: 20600108
    11. p53 might be involved in homologous recombination and/or checkpoint function by directly binding to DMC1 protein to repress genomic instability in meiotic germ cells PMID: 14764457
    12. The monomeric structure of the Dmc1 protein closely resembled those of the human and archaeal Rad51 proteins. We found another hydrogen bonding interaction at the polymer interface. PMID: 15125839
    13. hDmc1-mediated DNA recombination initiates through the nucleation of hDmc1 onto ssDNA to form a helical nucleoprotein filament PMID: 15164066
    14. N-terminal domain of DMC1 is required for the formation of the octamer, which may support the proper DNA binding activity of the DMC1 protein. PMID: 15917243
    15. activation of hDmc1 is mediated through conformational changes induced by free Ca2+ ion binding to a protein site that is distinct from the Mg2+.ATP-binding center PMID: 15917244
    16. BRCA2 binds the meiosis-specific recombinase DMC1 and define the primary DMC1 interaction site to a 26 amino-acid region PMID: 17541404
    17. Hop2/Mnd1 greatly stimulates Dmc1 to promote synaptic complex formation on long duplex DNAs PMID: 17639081
    18. Data show that DMC1 mutations may be one explanation for premature ovarian failure. PMID: 18166824
    19. The interaction of DMC1 and the homologue of the large subunit of CAF-1 is reported. PMID: 18355319
    20. Results indicate that Rad51 and Dmc1 filaments are essentially identical with respect to several structural parameters, including persistence length, helical pitch, filament diameter, DNA base pairs per helical turn and helical handedness. PMID: 18535008
    21. Biochemical analyses revealed that the human DMC1-M200V variant had reduced stability, and was moderately defective in catalyzing in vitro recombination reactions. PMID: 18566005
    22. Reversibility, equilibration, and fidelity of strand exchange reaction between short oligonucleotides promoted by RecA protein from escherichia coli and human Rad51 and Dmc1 proteins. PMID: 19004837
    23. DMC1-I37N polymorphism may be a source of improper meiotic recombination, causing meiotic defects in humans PMID: 19076215

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  • 亚细胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    RecA family, DMC1 subfamily
  • 数据库链接：

    HGNC: 2927

    OMIM: 602721

    KEGG: hsa:11144

    STRING: 9606.ENSP00000216024

    UniGene: Hs.339396