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DIS3L2 Antibody

  • 货号：
    CSB-PA818258LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human ovarian tissue using CSB-PA818258LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human bladder cancer using CSB-PA818258LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DIS3L2 Polyclonal antibody
  • Uniprot No.：
    Q8IYB7
  • 基因名：
    DIS3L2
  • 别名：
    DI3L2_HUMAN antibody; DIS3 L2 antibody; DIS3 mitotic control homolog (S. cerevisiae) like 2 antibody; DIS3 mitotic control homolog like 2 antibody; DIS3-like exonuclease 2 antibody; Dis3l2 antibody; FLJ36974 antibody; MGC42174 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human DIS3-like exonuclease 2 protein (201-400AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DIS3L2 Antibody (CSB-PA818258LA01HU)，的标记方式是Non-conjugated。对于DIS3L2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA818258LB01HU DIS3L2 Antibody, HRP conjugated ELISA
    FITC CSB-PA818258LC01HU DIS3L2 Antibody, FITC conjugated
    Biotin CSB-PA818258LD01HU DIS3L2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
  • 基因功能参考文献：
    1. The evidence has been presented that Dis3l2 controls miRNA-9 production. PMID: 27881476
    2. Our findings establish the role of DIS3L2 and oligouridylation as the cytoplasmic quality control for highly structured ncRNAs PMID: 27647875
    3. Studies indicate important roles of the exoribonucleases DIS3L2 and XRN1 in cellular function, viability and disease. PMID: 27911720
    4. these results indicate that catalytically inactive DIS3L2, characteristic of Perlman syndrome, can lead to deregulation of its target RNAs to disturb transcriptome homeostasis. PMID: 27431325
    5. DIS3L2 interacts with Ago2 and governs target RNA-directed miRNA degradation. PMID: 26809675
    6. DIS3L2 is the missing component of the LIN28-TUT4/7-DIS3L2 pathway required for the repression of let-7 in pluripotent cells. PMID: 24141620
    7. in cellular models DIS3L2 knockdown is associated with abnormalities of cell growth and division PMID: 23613427
    8. Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility. PMID: 22306653

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  • 相关疾病：
    Perlman syndrome (PRLMNS)
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, P-body.
  • 蛋白家族：
    RNR ribonuclease family, DIS3L2 subfamily
  • 数据库链接：

    HGNC: 28648

    OMIM: 267000

    KEGG: hsa:129563

    STRING: 9606.ENSP00000315569

    UniGene: Hs.732236