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DDX39A Antibody

  • 货号：
    CSB-PA006620ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: ATP-dependent RNA helicase DDX39A antibody at 2μg/ml
      Lane 1: A431 whole cell lysate
      Lane 2: 293T whole cell lysate
      Lane 3: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 50, 37, 31 kDa
      Observed band size: 50 kDa
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA006620ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA006620ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DDX39A Polyclonal antibody
  • Uniprot No.：
    O00148
  • 基因名：
    DDX39A
  • 别名：
    DDX39A antibody; DDX39 antibody; ATP-dependent RNA helicase DDX39A antibody; EC 3.6.4.13 antibody; DEAD box protein 39 antibody; Nuclear RNA helicase URH49 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human ATP-dependent RNA helicase DDX39A protein (178-427AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus.
  • 基因功能参考文献：
    1. DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation PMID: 28025139
    2. DDX39A is a potential biomarker for unfavorable neuroblastoma PMID: 26469522
    3. The protein levels of DDX39 were found to be higher in malignant pleural mesothelioma cell lines compared to normal pleural mesothelial cells. PMID: 23749908
    4. Results suggest that DDX39 is a suppressor of invasion and loss of its function predicts disease progression in bladder cancers. PMID: 22494014
    5. #NAME? PMID: 22119546
    6. Requirement of DDX39 DEAD box RNA helicase for genome integrity and telomere protection PMID: 21388492
    7. UAP56 and URH49 exhibit an intrinsic CRM1-independent nucleocytoplasmic shuttling PMID: 21799930
    8. Mx proteins exert their antiviral activity against IAV by interfering with the function of the RNA helicases UAP56 and URH49 PMID: 21859714
    9. Data show that the two closely related RNA helicases UAP56 and URH49 have evolved to form distinct mRNA export machineries, which regulate mitosis at different steps. PMID: 20573985
    10. Using a UL69 viral mutant that is unable to bind UAP56 and URH49, the s demonstrated that UL69's interaction with UAP56 or URH49 does not contribute to the growth phenotype associated with the UL69 deletion mutant. PMID: 20610707
    11. Regulation of URH49 mRNA expression and comparison with the related UAP56 RNA helicase. PMID: 15047853
    12. Reducing the expression of UAP56 and URH49 resulted in a reduction in reporter gene expression as well as cell death within 72 h suggest that both helicases have essential but largely overlapping functions in the processing and export of mammalian mRNAs. PMID: 16949217
    13. CIP29 physically and functionally associates with DDX39, suggesting their cooperation in the RNA metabolism. PMID: 17196963
    14. DDX39 is a novel RNA helicase capable of promoting cancer cell growth PMID: 17548965

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=Can translocate to the cytoplasm in the presence of MX1.
  • 蛋白家族：
    DEAD box helicase family, DECD subfamily
  • 组织特异性：
    Detected in testis, and at lower levels in brain, kidney, lung, thymus, spleen and salivary gland.
  • 数据库链接：

    HGNC: 17821

    KEGG: hsa:10212

    STRING: 9606.ENSP00000242776

    UniGene: Hs.311609