Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. Ctcfl Antibody

Ctcfl Antibody

  • 货号：
    CSB-PA006139LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Ctcfl antibody at 6µg/ml + Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 74, 75 kDa
      Observed band size: 74 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Ctcfl Polyclonal antibody
  • Uniprot No.：
    A2APF3
  • 基因名：
    Ctcfl
  • 别名：
    Ctcfl antibody; Boris antibody; Transcriptional repressor CTCFL antibody; Brother of the regulator of imprinted sites antibody; CCCTC-binding factor antibody; CTCF paralog antibody; CTCF-like protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse, Human
  • 免疫原：
    Recombinant Mouse Transcriptional repressor CTCFL protein (1-636AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Ctcfl Antibody (CSB-PA006139LA01MO)，的标记方式是Non-conjugated。对于Ctcfl Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA006139LB01MO Ctcfl Antibody, HRP conjugated ELISA
    FITC CSB-PA006139LC01MO Ctcfl Antibody, FITC conjugated
    Biotin CSB-PA006139LD01MO Ctcfl Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
  • 基因功能参考文献：
    1. CTCF and BORIS cooperate with additional Testis-specific transcriptional regulators to regulate gene expression in developing male gametes. PMID: 28145452
    2. The TGFB pathway as most affected by embryonic Ctcfl expression. PMID: 26169830
    3. down-regulation of endogenous BORIS by specific shRNAs inhibited both RNA transcription and cell cycle progression. The results altogether suggest a role for BORIS in coordinating S phase events with mitosis. PMID: 22724006
    4. Rb2 coimmunolocalizes with the chromatin insulator CCCTC-binding factor (CTCF) and BORIS in T-antigen-positive but not in T-antigen-negative cells. PMID: 22544282
    5. These findings show that BORIS expression is more widespread than previously believed, and suggest a role for BORIS in nucleolar function. PMID: 21811597
    6. These findings define transcriptional regulation of CST (Gal3st1) expression as a critical role for BORIS in spermatogenesis. PMID: 20231363
    7. CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region PMID: 18632606
    8. DNA damage-induced and ATR/Rfx1-mediated increase of miR-709 expression in exposed testes may be a protective mechanism that effectively decreases a cellular level of BORIS to prevent massive aberrant erasure of DNA methylation after radiation exposure. PMID: 19029807

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CTCF zinc-finger protein family
  • 组织特异性：
    Testis-specific.
  • 数据库链接：

    KEGG: mmu:664799

    STRING: 10090.ENSMUSP00000091845

    UniGene: Mm.389396