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Ccl6 Antibody

  • 货号：
    CSB-PA031049
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA031049(Ccl6 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P27784
  • 基因名：
    Ccl6
  • 别名：
    Ccl6 antibody; C10 antibody; Scya6C-C motif chemokine 6 antibody; Protein C10 antibody; Small-inducible cytokine A6) [Cleaved into: CCL6(22-95); CCL6(23-95)] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Mouse CCL6
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:500-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    CCL6(22-95) and CCL6(23-95) are potent chemoattractants.
  • 基因功能参考文献：
    1. Mice lacking RXRalpha in myeloid cells exhibit reduced levels of CCL6 and CCL9, impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis. PMID: 20498053
    2. enhanced expression in intestinal epithelium following immunostimulation with LPS or pro-inflammatory cytokines PMID: 19812544
    3. the injury-induced expression of C10 at the mRNA and protein level PMID: 11895334
    4. c10 promotes fibrosis by recruiting macrophages in the inflammatory response to bleomycin in the lung PMID: 12356575
    5. CCL6 gene activation and production induced by SCF in the presence or absence of rather specific inhibitors for certain pathways demonstrated that the MEK/MAPK pathway but not the PI-3K pathway was crucial for the SCF-induced CCL6 gene activation. PMID: 17234680
    6. the chemokines CCL6 and CCL9 as genes prominently induced by the type I IFNs and ICSBP PMID: 19171873

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 组织特异性：
    Expressed in myelopoietic bone marrow cultures stimulated by GM-CSF.
  • 数据库链接：

    KEGG: mmu:20305

    STRING: 10090.ENSMUSP00000019071

    UniGene: Mm.137