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CYP4F22 Antibody

  • 货号：
    CSB-PA740654LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HEK293 whole cell lysate, Hela whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate
      All lanes: CYP4F22 antibody at 3.2µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 62 kDa
      Observed band size: 62 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CYP4F22 Polyclonal antibody
  • Uniprot No.：
    Q6NT55
  • 基因名：
    CYP4F22
  • 别名：
    CYP4F22Cytochrome P450 4F22 antibody; EC 1.14.14.- antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cytochrome P450 4F22 protein (413-507AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CYP4F22 Antibody (CSB-PA740654LA01HU)，的标记方式是Non-conjugated。对于CYP4F22 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA740654LB01HU CYP4F22 Antibody, HRP conjugated ELISA
    FITC CSB-PA740654LC01HU CYP4F22 Antibody, FITC conjugated
    Biotin CSB-PA740654LD01HU CYP4F22 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    A cytochrome P450 monooxygenase involved in epidermal ceramide biosynthesis. Hydroxylates the terminal carbon (omega-hydroxylation) of ultra-long-chain fatty acyls (C28-C36) prior to ceramide synthesis. Contributes to the synthesis of three classes of omega-hydroxy-ultra-long chain fatty acylceramides having sphingosine, 6-hydroxysphingosine and phytosphingosine bases, all major lipid components that underlie the permeability barrier of the stratum corneum. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
  • 基因功能参考文献：
    1. patients carrying one or two truncating CYP4F22 mutations affecting the SBRs tend to develop collodion membrane at birth PMID: 27735052
    2. We report two cases of Congenital Ichthyosiform Erythroderma showing homozygous mutations in the gene CYP4F22. PMID: 26646773
    3. description of CYP4F22 mutations from a Japanese collodion baby with lamellar ichthyosis [case report] PMID: 23871423
    4. Letter: CYP4F22 is highly expressed at the site and timing of onset of keratinization during skin development. PMID: 22209317
    5. REVIEW: genetic analyses have identified a wide spectrum of mutations in the CYP4V2gene from patients suffering from Bietti's crystalline corneoretinal dystrophy, and mutations in theCYP4F22 gene have been linked to lamellar ichthyosis PMID: 21540472

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  • 相关疾病：
    Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein. Microsome membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 数据库链接：

    HGNC: 26820

    OMIM: 604777

    KEGG: hsa:126410

    STRING: 9606.ENSP00000269703

    UniGene: Hs.156452