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CUX1 Antibody

  • 中文名称：
    CUX1兔多克隆抗体
  • 货号：
    CSB-PA006228LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of Hela cells with CSB-PA006228LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CUX1 Polyclonal antibody
  • Uniprot No.：
    P39880
  • 基因名：
    CUX1
  • 别名：
    CUX1 antibody; CUTL1Homeobox protein cut-like 1 antibody; CCAAT displacement protein antibody; CDP antibody; Homeobox protein cux-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Homeobox protein cut-like 1 protein (24-94AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CUX1 Antibody (CSB-PA006228LA01HU)，的标记方式是Non-conjugated。对于CUX1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA006228LB01HU CUX1 Antibody, HRP conjugated ELISA
    FITC CSB-PA006228LC01HU CUX1 Antibody, FITC conjugated
    Biotin CSB-PA006228LD01HU CUX1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator.; Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1.
  • 基因功能参考文献：
    1. Our data indicate that there exist frameshift mutations of CUX1 and SIRT1 genes as well as intratumoral heterogeneity of CUX1 frameshift mutation in high microsatellite instability cancers, which together might play a role in tumorigenesis of gastric cancer and colorectal cancer with high microsatellite instability PMID: 29363918
    2. CUX1 is enriched at sites of DNA looping, as determined by Hi-C analysis, and these loops connect CUX1 to the promoters of regulated genes. PMID: 28369554
    3. our results have uncovered the requirement for CUX1 expression in cancer cells with elevated reactive oxygen species levels PMID: 28147323
    4. Study found are higher CUTL1 expression level in non-small cell lung cancer (NSCLC) tissues and showed that CUTL1 induced epithelial-mesenchymal transition in NSCLC. PMID: 28405678
    5. Results show that Cux1 is expressed in cerebellar granule cell precursors and downregulated as they terminally differentiate; coexpression analysis in human medulloblastomas suggests another function related to DNA integrity and stability PMID: 25096634
    6. High CUX1 expression is associated with metastasis in pancreatic neuroendocrine neoplasms. PMID: 25248790
    7. s identified CUX1 as an important modulator of the TAMs phenotype and function by modulating NF-kappaB-dependent cytokines. PMID: 24336331
    8. This is a novel gene implicated in atrial fibrillation PMID: 25124494
    9. CASP is specifically cleaved by granzymeB. PMID: 25159843
    10. Suggest that CUTL1 may regulate the proliferation of malignant melanoma by modulating the expression of cell cycle-related proteins. PMID: 24686420
    11. CUX1 expression is associated with tumour progression and tumor burden. [Review] PMID: 25190083
    12. Loss of CUX1 is associated with myeloid neoplasms. PMID: 24429498
    13. Cux1 is a tumor suppressor and inactivating CUX1 mutations promote tumorigenesis. PMID: 24316979
    14. Our results provide the first evidence that polymorphisms of the CUX1 gene may be associated with response to antidepressant treatment in Japanese patients with MDD. PMID: 22584459
    15. p110 CUX1 can mediate transcriptional repression or activation of specific genes when bound at variable distances from the transcription start site. PMID: 23590133
    16. s found that both chromosomal inversions target the cut-like homeobox 1 (CUX1) gene on chromosomal band 7q22.1 in a way which is functionally equivalent to the more frequently observed del(7q) cases. PMID: 22965931
    17. Cutl1 played transcriptional level mediated by signal transduction, translational level mediated by miR122, posttranslational level such as phosphorylation, de-phosphorylation, acetylation and proteolytic cleavage. PMID: 23085261
    18. overexpression of active CUTL1 significantly resulted in increased cancer tissue response to chemotherapy and therefore inhibited growth, whereas knockdown of CUTL1 conferred resistance to chemotherapy. PMID: 23255599
    19. Data indicate CUX1 as a conserved, haploinsufficient tumor suppressor frequently deleted in myeloid neoplasms. PMID: 23212519
    20. The data demonstrates that the autism spectrum disorder-associated A-C intronic haplotype of the ENGRAILED2 gene is a transcriptional activator, and both CUX1 and NFIB mediate this activity. PMID: 22180456
    21. we find repression of apoptosis regulators by Cux1 in human cancer cells. PMID: 22438831
    22. cux1 is associated with cell functions and human disease. PMID: 22306263
    23. modifications of CUX1 expression lead to aberrant expression of type I collagen, which may provide a molecular basis for fibrogenesis PMID: 21471005
    24. we identified a novel CUX1-FGFR1 fusion oncogene in a patient with the 8p11 myeloproliferative syndrome and demonstrated its transforming potential in the Ba/F3 cell line. PMID: 21330321
    25. screening for mutations in CUX1 using 15 secondary acute myeloid leukemia cases with preceding myeloproliferative neoplasms or loss-of-heterozygosity on chromosome 7q (collaborative study in several countries) PMID: 21674579
    26. Transcriptional targets of CUX1 involved in DNA replication and bipolar mitosis defined a gene expression signature that, across 12 breast cancer gene expression datasets, was associated with poor clinical outcome. PMID: 21245318
    27. Elevated levels of cux1 are associated with inflammatory bowel disease. PMID: 20848487
    28. GRIA3 plays a role as a mediator of tumor progression in pancreatic cancer downstream CUX1. PMID: 20689760
    29. data indicate that CUX1 represents an important survival factor downstream of PI3K/Akt, which orchestrates a transcriptional programme mediating resistance to apoptosis in pancreatic cancer. PMID: 20442202
    30. findings show that CUTL1 expression is gradually silenced at the posttranscriptional level during liver development; overexpression and knockdown studies that miR-122 repressed CUTL1 protein expression in HCC cell lines PMID: 20842632
    31. Transfection of keratinocytes with plasmid DNA leads to the loss of detectable DNA-binding activity of CCAAT displacement protein. PMID: 11953010
    32. Analysis of flanking sequences of IgH and Ig kappa V region genes show extensive heterogeneity in frequency and location of CDP binding sites and capability of CDP to bind to the nuclear matrix. PMID: 12193717
    33. Data report the characterization of a mammalian coiled-coil protein, CASP, a Golgi protein that shares with giantin a conserved histidine in its transmembrane domain. PMID: 12429822
    34. Lack of LF expression in the acute promyelocytic leukemia cell line NB4 is associated with the persistent binding of the silencer CCAAT displacement protein (CDP/cut) to the LF promoter in these cells. PMID: 12522000
    35. correlation between binding of CDP/Cux to the DNA pol alpha promoter and the stimulation of gene expression PMID: 12665598
    36. CDP, in conjunction with one or more viral proteins, binds to the packaging sequences of Adenovirus type 5 to initiate the encapsidation process PMID: 12743282
    37. our data suggested that somatic mutations in CDP gene were rare in unselected uterine leiomyomas PMID: 12766905
    38. interaction of G9a with a sequence-specific transcription factor that regulates gene repression through CDP/cut. PMID: 15269344
    39. CUTL1 plays a central role in coordinating a gene expression program associated with cell motility and tumor progression. PMID: 15950902
    40. Binding of E2 at the binding sites play an important role in overcoming inhibition of E1 complex formation caused by the binding of CDP to the origin of replication. PMID: 16529788
    41. PKA-induced phosphorylation results in decreased DNA binding affinity of CUTL1 and diminished CUTL1-mediated cell cycle progression and cell motility. PMID: 16574653
    42. Single Nucleotide Polymorphism in CUTL1 is associated with myeloid neoplasias PMID: 17140660
    43. CUTL1 transcriptionally up-regulates WNT5A on RNA, protein and promoter level. PMID: 17227781
    44. Src plays a crucial role in CUTL1-induced tumor cell migration PMID: 17369846
    45. CDP inhibits cytokine-induced NF-kappaB-regulated chemokine transcription in melanoma cells PMID: 17496784
    46. CUX1 C-terminal proteolytic processing by a caspase enables transcriptional activation in proliferating cells PMID: 17681953
    47. Data show that in renal cell carcinoma, the Cut-like homeodomain protein is involved in FIH-1 transcriptional regulation and is controlled by a specific signaling event involving protein kinase C zeta. PMID: 17682059
    48. The data strongly suggest that CDP acts as a major suppressor for Human papillomavirus type 16 P670 transcription by binding to the promoter region in the undifferentiated cells PMID: 17957475
    49. Genome-wide location analysis revealed that targets common to p110 CUX1 and E2F1 included many genes involved in cell cycle, DNA replication, and DNA repair. PMID: 18347061
    50. This result revealed a negative feedback loop whereby CUX1 shuts down the expression of the protease that cleaves it. PMID: 18403643

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    CUT homeobox family
  • 数据库链接：

    HGNC: 2557

    OMIM: 116896

    STRING: 9606.ENSP00000353401

    UniGene: Hs.191482