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CTNND2 Antibody

  • 货号：
    CSB-PA892496LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA892496LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA892496LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CTNND2 Polyclonal antibody
  • Uniprot No.：
    Q9UQB3
  • 基因名：
    CTNND2
  • 别名：
    ARM-repeat protein antibody; Catenin (cadherin associated protein) delta 2 antibody; catenin (cadherin-associated protein); delta 2 (neural plakophilin-related arm-repeat protein) antibody; Catenin delta 2 antibody; Catenin delta-2 antibody; CTND2_HUMAN antibody; CTNND 2 antibody; Ctnnd2 antibody; Delta catenin antibody; Delta-catenin antibody; GT 24 antibody; GT24 antibody; Neural plakophilin related arm repeat protein antibody; Neural plakophilin related armadillo repeat protein antibody; Neural plakophilin-related ARM-repeat protein antibody; Neural plakophilin-related; Neurojungin antibody; Neurojungin antibody; NPRAP antibody; T cell delta catenin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Catenin delta-2 protein (4-308AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CTNND2 Antibody (CSB-PA892496LA01HU)，的标记方式是Non-conjugated。对于CTNND2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA892496LB01HU CTNND2 Antibody, HRP conjugated ELISA
    FITC CSB-PA892496LC01HU CTNND2 Antibody, FITC conjugated
    Biotin CSB-PA892496LD01HU CTNND2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation. Functions as a transcriptional activator when bound to ZBTB33. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.
  • 基因功能参考文献：
    1. Data provide evidence that delta-catenin may serve an important role in the malignancy of lung adenocarcinoma through activation of canonical Wnt signaling and cancer stem cell maintenance. PMID: 29251319
    2. Gene Ontology analysis revealed that neuronal differentiation-related genes were enriched among targets that were co-regulated by REST and TRIM28, while the level of CTNND2 was increased by the knockdown of REST and TRIM28. Consistently, during neuronal differentiation, the level of CTNND2 increased while those of REST and TRIM28 decreased, suggesting that CTNND2 expression may be co-regulated by both. PMID: 27976729
    3. We propose CTNND2 as the causal gene infamilial cortical myoclonic tremor and epilepsy-3 PMID: 29127138
    4. At the molecular level, CTNND2 is at the crossroad with interactions to such signaling pathways of Wnt and Rho family small GTPases in the Ras superfamily, which are known to drive human disease pathogenesis. PMID: 27380241
    5. Our data suggested that genetic variants in GRM6 are associated with high myopia. The mechanism of GRM6 in the development of high myopia need to be further investigated. PMID: 27034204
    6. Multigenerational autosomal dominant inheritance of 5p chromosomal deletions resulting in Cri-du-Chat Syndrome with SEMA5A, CTNND2, and ICE1 deficiencies has been described. PMID: 26601658
    7. the effect of CTNND2 polymorphisms on normal variability and identified a polymorphism (rs2561622) with significant effect on phonological ability and white matter volume in the left frontal lobe, was investigated. PMID: 25473103
    8. Study describes two Ion-syndromic intellectual disability cases, positive for the presence of a small copy number variants, intragenic CTNND2 gene deletion. PMID: 25839933
    9. Results conclude that the introduction of CTNND2 gene variation is an important milestone in prostate cancer metabolic adaptation. PMID: 24727894
    10. co-expression of Delta-catenin and RhoA was significantly associated with histological type, differentiation, pTNM stage, lymphatic metastasis and a poor prognosis in non-small cell lung cancer PMID: 25120748
    11. our results suggest that delta-catenin acts as an oncoprotein when overexpressed in esophageal squamous cell carcinoma PMID: 25090917
    12. SNPs in CTNND2 showed an increased signal for schizophrenia and major depressive disorder, but not for bipolar disorder. The association between CTNND2 and anxiety was not strong enough in current generation of human genome-wide analyses. PMID: 24256404
    13. delta-catenin upregulates the activity of cdc42 and Rac1 GTPases at transcriptional level, and their coexpression predict a poor clinical outcome in nonsmall cell lung cancer patients PMID: 22213037
    14. Genome-wide significant association with CTNND2 single nucleotide polymorphisms rs17183619, rs13155993 and rs13170756 for the bivariate outcome of cortical cataract and temporal horn volume, is reported. PMID: 22984439
    15. Specific polymorphisms in the CTNND2 gene and 11q24.1 genomic region were found to be significantly associated with pathological myopia in this Chinese population. PMID: 22759899
    16. Multiple genes linked to Alzheimer's disease are regulated by NPRAP. Furthermore, NPRAP nuclear translocation is required for gene regulation. PMID: 21811021
    17. These results confirmed the strong association between CTNND2 polymorphism and myopia. PMID: 21911587
    18. The studies support coordinated regulation of delta-catenin expression by both the activating transcription factor E2F1 and repressive transcription factor Hes1 in prostate cancer progression. PMID: 21106062
    19. This study identified a strong association of CTNND2 for high myopia in Asian datasets. The CTNND2 gene maps to a known high myopia linkage region on chromosome 5p15. PMID: 21095009
    20. The delta catenin is essential for N-cadherin-mediated formation of proper junctional structures and thereby the establishment of the cell polarity. PMID: 20859058
    21. Cells overexpressing delta-catenin have less p120-catenin than control cells at the cell-cell interface, causing the relocalization of p120-catenin from the plasma membrane to the cytosol. CTNND2 binding to E-cadherin adversely affects CTNND1 stability. PMID: 20108168
    22. Data report that either Pax6(+5a) or Pax6(-5a) was sufficient to promote, whereas their knockdown reduced the expression of delta-catenin (CTNND2), a neural specific member of the armadillo/beta-catenin superfamily. PMID: 20074565
    23. Increased expression of delta-catenin is associated with the down-regulation and redistribiution of ECAD and p120ctn in prostatic cancer. PMID: 16226102
    24. The interaction of scaffolding proteins with cadherin-NPRAP complexes anchors diverse signaling and adhesion molecules at cadherins. PMID: 17687028
    25. These studies identify E2F1 as a positive transcriptional regulator for delta-catenin. PMID: 18302937
    26. Increased nucleotide polymorphic changes in the 5'-untranslated region of delta-catenin (CTNND2) gene in prostate cancer. PMID: 18978817

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  • 相关疾病：
    Defects in CTNND2, including deleterious missense and copy number variants (CNVs) are involved in autism, a complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.
  • 亚细胞定位：
    Nucleus. Cell junction, adherens junction. Cell projection, dendrite. Perikaryon.
  • 蛋白家族：
    Beta-catenin family
  • 组织特异性：
    Expressed in brain; highest expression is observed in fetal brain.
  • 数据库链接：

    HGNC: 2516

    OMIM: 604275

    KEGG: hsa:1501

    STRING: 9606.ENSP00000307134

    UniGene: Hs.314543