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CTNNA2 Antibody

  • 货号：
    CSB-PA006165GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P26232
  • 基因名：
  • 别名：
    Alpha catenin related protein antibody; Alpha N catenin antibody; Alpha N-catenin antibody; Alpha-catenin-related protein antibody; Cadherin associated protein related antibody; Cancer/testis antigen 114 antibody; CAP R antibody; CAPR antibody; Catenin (cadherin associated protein) alpha 2 antibody; Catenin alpha 2 antibody; Catenin alpha-2 antibody; CT114 antibody; CTNA2_HUMAN antibody; CTNN A2 antibody; CTNNA 2 antibody; CTNNA2 antibody; CTNR antibody; DKFZp686H02198 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CTNNA2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.
  • 基因功能参考文献：
    1. Single nucleotide polymorphisms in CTNNA2 show associations in Schizophrenia and general cognitive function. PMID: 28746715
    2. One association in the CTNNA2 gene on chromosome 2p12 [rs1567532, hazard ratio (HR) = 1.75, 95% confidence interval (CI) 1.19-2.58, P = 0.005 for homozygotes for the minor allele] and one in the last intron of the RUNX2 gene on chromosome 6p21 (rs12209785, HR = 0.88, 95% CI 0.80-0.98, P = 0.014 for heterozygotes) are of particular relevance. These loci do not coincide with those that showed the strongest associations in t PMID: 27497070
    3. SNP 50-kb upstream from CTNNA2 was associated with impulsivity in Native American sample. PMID: 27167163
    4. Single nucleotide polymorphism in CTNNA2 is associated with breast cancer susceptibility. PMID: 25824743
    5. CTNNA2 gene increases the risk of alcohol addiction in White women. PMID: 25041903
    6. CTNNA2 and CTNNA3 are tumor suppressor genes frequently mutated in laryngeal carcinomas. PMID: 24100690
    7. Common variants in CTNNA2 are associated with excitement-seeking and risk-taking. PMID: 22833195
    8. CTNNA2 is differentially regulated by smoking in schizophrenic patients. PMID: 18163523
    9. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18519826

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell projection, axon. Nucleus.
  • 蛋白家族：
    Vinculin/alpha-catenin family
  • 组织特异性：
    Expressed in neural tissues, with strongest expression in fetal and adult brain. Expressed in the developing cortical plate and marginal zone of 20-week-old human fetal brain.
  • 数据库链接：

    HGNC: 2510

    OMIM: 114025

    KEGG: hsa:1496

    UniGene: Hs.167368