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CSE1L Antibody

  • 货号：
    CSB-PA001218
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using CAS Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P55060
  • 基因名：
    CSE1L
  • 别名：
    CSE1L; CAS; XPO2; Exportin-2; Exp2; Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human CAS.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IP, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IP 2-5ug
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
  • 基因功能参考文献：
    1. CSE1L expression was correlated with MSH6 expression in tumor samples and was associated with poor prognosis in patients with osteosarcoma. Taken together, our results demonstrate that the CSE1L-MSH6 axis has an important role in osteosarcoma progression. PMID: 28387323
    2. CSE1L appears to be critical for the nuclear import of certain key repressive proteins. Indeed, NOVA1, HDAC1, HDAC2, and HDAC8, genes known as silencing factors, became delocalized into cytosol upon CSE1L depletion. PMID: 29636421
    3. The combination of CTNB1, XPO2, and CAPG achieved 95% sensitivity and 96% specificity for the discrimination of these subtypes. We developed two uterine aspirate-based signatures to diagnose Endometrial cancer and classify tumors in the most prevalent histologic subtypes. This will improve diagnosis and assist in the prediction of the optimal surgical treatment PMID: 28790116
    4. Our data suggest a previously unanticipated link between CAS and integrin beta1 signaling which correlates with an aggressive hepatocellular carcinoma phenotype. PMID: 27015362
    5. CSE1L knockdown by shRNA inhibited protein, resulting in decreased cell proliferation, reduced colony formation in soft agar, and induction of apoptosis. CSE1L protein is expressed early and across all stages of colorectal carcinoma (CRC) development. shRNA knockdown of CSE1L was associated with inhibition of tumorigenesis in CRC cells. CSE1L may represent a potential target for treatment of CRC. PMID: 27521996
    6. Data suggest that CAS overexpression in thyroid carcinoma depends on the subtype and the disease stage. Our findings also indicate that CAS maintains papillary thyroid cell proliferation and survival. PMID: 26892809
    7. There is a relationship between nuclear CSE1L overexpression and distant metastasis in breast cancer. PMID: 26278417
    8. CAS plays contrasting roles in proliferation and apoptosis PMID: 26668314
    9. hCAS/CSE1L is responsible for controlling the homologous recombinational repair activity by directly interacting with RAD51. PMID: 26123175
    10. nuclear CSE1L is mainly non-phosphorylated CSE1L and is involved in gene regulation and cytoplasmic CSE1L is mainly phosphorylated CSE1L and is involved in cytoplasmic signaling regulation in melanocytic tumorigenesis. PMID: 25973023
    11. These results indicate that CSE1L is associated with viability and apoptosis, cellular adhesion and invasion, thus implicating CSE1L in the progression of colorectal cancer. PMID: 22450763
    12. The cellular apoptosis susceptibility/importin-alpha1 transport cycle is linked to X-linked inhibitor (XIAP) and is required to maintain tumor cell survival in hepatocellular carcinoma. PMID: 24799195
    13. CSE1L expression was significantly inhibited in RKO cells, causing cell cycle arrest in the G2/M and S phases and a delay in cell proliferation, as well as induction of apoptosis and an inhibition of colony growth capacity. PMID: 23621178
    14. Most colorectal tumors were positive for CSE1L staining (98.4%). CRT's with K-Ras mutation or high cytoplasmic CSE1L expression were correlated with T status (depth of tumor penetration; P = .004), stage (P = .004), and lymph node metastasis (P = .019). PMID: 23806821
    15. Our results suggest that urinary CSE1L deserves further evaluation for the screening of bladder cancer. PMID: 22653741
    16. CSE1L- and inhibitor of DNA binding-3 (ID3)-overexpression was associated with the diagnosis of BL and signal transduction and transcription-3 (STAT3) with DLBCL (P<0.001 for all markers). All three markers were associated with patient outcome in DLBCL PMID: 22967991
    17. CSE1L may be involved in the "early" and "late" metastasis of tumor cells in tumorigenesis. PMID: 22952058
    18. Nuclear CSE1L may play an oncogenic role in bladder tumor progression and that immunohistochemical staining of nuclear CSE1L may be useful for the prognosis of bladder urothelial carcinomas. PMID: 22476051
    19. CAS protein expression is related closely to tumor differentiation in hepatocellular carcinoma tissues. PMID: 23189846
    20. Data show that CSE1L, DIDO1 and RBM39 mRNA expression levels correlated with chromosome 20q DNA copy number status. PMID: 22711543
    21. the requirement for and the regulation of CAS in the functioning of the Vpr-Impalpha complex PMID: 22110766
    22. Increased immunoexpression of CAS protein in serous ovarian tumors may be useful in identifying the patients with more aggressive disease. PMID: 21290345
    23. These results indicate that examination of CSE1L and E-cadherin distribution in colorectal epithelium glands may be valuable for evaluating the malignance of colorectal disease. PMID: 20734115
    24. Serum cellular apoptosis susceptibility protein may have a role in progression of metastatic colorectal cancer PMID: 20150437
    25. CAS/CSE 1 stimulates E-cadhrin-dependent cell polarity in HT-29 human colon epithelial cells. PMID: 12061792
    26. CSE1L/CAS has a role in proliferation and apoptosis [review] PMID: 12510150
    27. a single phosphorylation site on CAS can effectively separate cell migration from other transformed growth characteristics PMID: 12972425
    28. Results suggested that CAS may be associated with cell proliferation rather than apoptosis, and further, CAS might play an important role in the development of human hepatocellular carcinoma. PMID: 16786158
    29. hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes. PMID: 17719542
    30. These results indicate that CAS may play an important role in regulating the cytotoxicities of chemotherapeutic drugs. PMID: 18377724
    31. Results show that heat upregulates the initial docking of importin-alpha at the nuclear envelope and stimulates the translocation of cellular apoptosis susceptibility protein into the nuclear interior. PMID: 18425415
    32. PHAPI, CAS, and Hsp70 function together to accelerate nucleotide exchange on Apaf-1 and prevent inactive Apaf-1/cytochrome c aggregation. PMID: 18439902
    33. Herein, we report that cellular apoptosis susceptibility (CAS) (or CSE1L) protein regulates the secretion of HT-29 human colorectal cells. PMID: 19224336

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    XPO2/CSE1 family
  • 组织特异性：
    Detected in brain, placenta, ovary, testis and trachea (at protein level). Widely expressed. Highly expressed in testis and in proliferating cells.
  • 数据库链接：

    HGNC: 2431

    OMIM: 601342

    KEGG: hsa:1434

    STRING: 9606.ENSP00000262982

    UniGene: Hs.90073