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CRYZ Antibody

  • 货号：
    CSB-PA600843LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA600843LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA600843LA01HU diluted at 1:400 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CRYZ Polyclonal antibody
  • Uniprot No.：
    Q08257
  • 基因名：
    CRYZ
  • 别名：
    Crystallin zeta (quinone reductase) antibody; Crystallin zeta antibody; Cryz antibody; DKFZp779E0834 antibody; FLJ41475 antibody; NADPH:quinone reductase antibody; QOR_HUMAN antibody; Quinone oxidoreductase antibody; Zeta crystallin antibody; Zeta-crystallin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Quinone oxidoreductase protein (47-109AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CRYZ Antibody (CSB-PA600843LA01HU)，的标记方式是Non-conjugated。对于CRYZ Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA600843LB01HU CRYZ Antibody, HRP conjugated ELISA
    FITC CSB-PA600843LC01HU CRYZ Antibody, FITC conjugated
    Biotin CSB-PA600843LD01HU CRYZ Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.
  • 基因功能参考文献：
    1. Our results suggest that genetic variants in TYW3/CRYZ and NDST4 loci may be involved in the regulation of circulating resistin levels PMID: 22843503
    2. role of Zta1p in the yeast adaptation to some stress types and the general functional significance of zeta-crystallins PMID: 21276778
    3. novel enzymatic activity for human zeta-crystallin, the double- bond a,b-hydrogenation of 2-alkenals and 3-alkenones, was identified. PMID: 20835842
    4. zeta-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia. PMID: 20103721
    5. up-regulation of quinone reductase can protect breast cells against oxidative DNA damage PMID: 12714703

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Zinc-containing alcohol dehydrogenase family, Quinone oxidoreductase subfamily
  • 组织特异性：
    Only very low amounts in the lens.
  • 数据库链接：

    HGNC: 2419

    OMIM: 123691

    KEGG: hsa:1429

    STRING: 9606.ENSP00000339399

    UniGene: Hs.83114