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CPSF2 Antibody

  • 货号：
    CSB-PA005916GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9P2I0
  • 基因名：
    CPSF2
  • 别名：
    Cleavage and polyadenylation specific factor 2 antibody; cleavage and polyadenylation specific factor 2; 100kDa antibody; Cleavage and polyadenylation specificity factor 100 kDa subunit antibody; Cleavage and polyadenylation specificity factor subunit 2 antibody; CPSF 100 kDa subunit antibody; CPSF 2 antibody; CPSF100 antibody; Cpsf2 antibody; CPSF2_HUMAN antibody; KIAA1367 antibody; zgc:92484 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CPSF2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing.
  • 基因功能参考文献：
    1. CPSF2 may have a role in Papillary Thyroid Carcinoma PMID: 26148673
    2. CPSF2 and SYMPK, are RBFOX2 cofactors for both inclusion and exclusion of internal exons. PMID: 25921069
    3. Decreased CPSF2 expression is associated with increased cellular invasion and cancer stem cell population, and more aggressive disease in papillary thyroid cancer. PMID: 24654752
    4. Conserved residues in CPSF2 and CPSF-73 are required for assembly of the endonuclease activity that cleaves histone pre-mRNAs. PMID: 18688255
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Metallo-beta-lactamase superfamily, RNA-metabolizing metallo-beta-lactamase-like family, CPSF2/YSH1 subfamily
  • 数据库链接：

    HGNC: 2325

    OMIM: 606028

    KEGG: hsa:53981

    STRING: 9606.ENSP00000298875

    UniGene: Hs.657632