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CPA1 Antibody

  • 货号：
    CSB-PA001768
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of K562 cells using CPA1 Polyclonal Antibody
    • Western Blot analysis of K562 cells using CPA1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P15085
  • 基因名：
    CPA1
  • 别名：
    carboxypeptidase A1 (pancreatic) antibody; Carboxypeptidase A1 antibody; Carboxypeptidase A1 precursor antibody; CBPA1_HUMAN antibody; CPA antibody; CPA1 antibody; Pancreatic carboxypeptidase A1 antibody; Procarboxypeptidase A1 pancreatic antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CPA1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond.
  • 基因功能参考文献：
    1. study indicates ER stress-inducing variants in CPB1 and CPA1 are associated with pancreatic cancer susceptibility and implicate ER stress in pancreatic acinar cells in pancreatic cancer development. PMID: 29669919
    2. Data found no significant enrichment of rare functionally defective CPA1 variants in a large Chinese idiopathic chronic pancreatitis cohort PMID: 28497564
    3. Gene mutations were present in PRSS1 in 26 patients with acute recurrent and chronic pancreatitis, SPINK1 in 23, CTRC in 3, and CPA1 in 5. In the 31 patients with mutations in SPINK1, CTRC, or CPA1, 16 (51.6%) had homozygous or heterozygous mutations with other mutations. PMID: 27409067
    4. Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2. PMID: 27358403
    5. mechanism by which CPA1 variants confer increased pancreatitis risk may involve misfolding-induced endoplasmic reticulum stress rather than elevated trypsin activity PMID: 23955596
    6. Serum pro-CPA and CPA levels were increased in either pancreatitis or pancreatic malignancy PMID: 21502183
    7. A description of the ternary complex hCPA1-Zn2+-poly(acrylic acid) is included as a model of the interaction of mucoadhesive polymers with proteases in the gastrointestinal tract. PMID: 18566513

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase M14 family
  • 数据库链接：

    HGNC: 2296

    OMIM: 114850

    KEGG: hsa:1357

    STRING: 9606.ENSP00000011292

    UniGene: Hs.2879