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CNNM2 Antibody

  • 货号：
    CSB-PA872518LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA872518LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA872518LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CNNM2 Polyclonal antibody
  • Uniprot No.：
    Q9H8M5
  • 基因名：
    CNNM2
  • 别名：
    ACDP2 antibody; Ancient conserved domain containing protein 2 antibody; Ancient conserved domain protein 2 antibody; Ancient conserved domain-containing protein 2 antibody; CNNM 2 antibody; CNNM2 antibody; CNNM2_HUMAN antibody; Cyclin M2 antibody; Cyclin-M2 antibody; Metal transporter CNNM2 antibody; OTTHUMP00000020387 antibody; OTTHUMP00000020388 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Metal transporter CNNM2 protein (739-875AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CNNM2 Antibody (CSB-PA872518LA01HU)，的标记方式是Non-conjugated。对于CNNM2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA872518LB01HU CNNM2 Antibody, HRP conjugated ELISA
    FITC CSB-PA872518LC01HU CNNM2 Antibody, FITC conjugated
    Biotin CSB-PA872518LD01HU CNNM2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+).
  • 基因功能参考文献：
    1. CNNM2 single nucleotide polymorphisms association with the risk of hypertension in Chinese Han population. PMID: 30180964
    2. In this large-scale, Han Chinese population-based genetic association study for genetic susceptibility to schizophrenia of a three-gene cluster region, AS3MT-CNNM2-NT5C2, two SNPs with independent effects, rs11191419 and rs11191514, were identified. Rs11191419 is located on the 5' (potential promoter) region of AS3MT, while rs11191514 is located in one of the introns of CNNM2. PMID: 27401531
    3. this study implicates altered neural expression of BORCS7, AS3MT, and NT5C2 in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus PMID: 27004590
    4. Sensitivity of CNNM2 expression to extracellular Mg(2+) depletion depends on cell type. PMID: 27068403
    5. meta-analysis of two Caucasian cohorts did not show an association between five aneurysm associated loci and sporadic brain Arteriovenous malformations. PMID: 25053769
    6. The T568I mutation causes the magnesium transporter, CNNM2, to become 'locked' in its flat form. PMID: 25184538
    7. Cells expressing mutated CNNM2 proteins did not show increased Mg(2+) uptake. PMID: 24699222
    8. This CNNM2 risk variant rs7914558 may have an impact on neural systems relevant to social cognition. PMID: 24311551
    9. Our findings suggest that the genetic variant in the CNNM2 gene could be implicated in the pathogenesis of schizophrenia through the gray matter volumetric vulnerability of the orbital regions in the inferior frontal gyri. PMID: 24160291
    10. crystals of CNNM2 belonged to space groups P2(1)2(1)2 and I222 (or I2(1)2(1)2(1)) and diffracted X-rays to 2.0 and 3.6 A resolution, respectively, using synchrotron radiation PMID: 23027747
    11. analysis of structure of CNNM2 and its post-translational modifications PMID: 22399287
    12. ACDP2 splice-variant 1 is a functional Mg2+-transporting entity per se. PMID: 20519162
    13. The CNNM2 locus is associated with serum Mg(2+) concentrations. PMID: 21397062

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  • 相关疾病：
    Hypomagnesemia 6 (HOMG6); Hypomagnesemia, seizures, and mental retardation (HOMGSMR)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ACDP family
  • 组织特异性：
    Widely expressed. Expressed at higher level in brain, kidney and placenta, while it is weakly expressed in skeletal muscle. In the kidney, it is expressed in the distal convoluted tubule and the thick ascending limb of Henle loop.
  • 数据库链接：

    HGNC: 103

    OMIM: 607803

    KEGG: hsa:54805

    STRING: 9606.ENSP00000358894

    UniGene: Hs.643509