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CMIP Antibody

  • 货号：
    CSB-PA815577LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA815577LA01HU diluted at 1:600 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CMIP Polyclonal antibody
  • Uniprot No.：
    Q8IY22
  • 基因名：
    CMIP
  • 别名：
    C-Maf-inducing protein antibody; c-Mip antibody; cmip antibody; CMIP_HUMAN antibody; KIAA1694 antibody; Tc-Mip antibody; TCMIP antibody; Truncated c-Maf-inducing protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human C-Maf-inducing protein (157-274AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CMIP Antibody (CSB-PA815577LA01HU)，的标记方式是Non-conjugated。对于CMIP Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA815577LB01HU CMIP Antibody, HRP conjugated ELISA
    FITC CSB-PA815577LC01HU CMIP Antibody, FITC conjugated
    Biotin CSB-PA815577LD01HU CMIP Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.
  • 基因功能参考文献：
    1. Genome-wide significant (P < 5 x 10(-8) ) interaction with MTNR1B and joint effects were detected for CMIP intronic rs17197883. PMID: 29691896
    2. each copy of CMIP rs2925979_T allele was associated with a 29% higher risk of T2DM in females (p = 9.30 x 10(-4)), while it was not significantly associated with T2DM in males (p = 0.705). PMID: 29597287
    3. CMIP knockdown was observed to result in the downregulation of MDM2 and mitogen activated protein kinase (MAPK) expression at the mRNA level and CMIP was a direct target of miR1013p. PMID: 28944848
    4. CMIP is oncogenic and could be a potential target for human glioma diagnosis and therapy. PMID: 28744466
    5. These findings suggest that CMIP haploinsufficiency is the likely cause of syndromic Autism spectrum disorder in our patients. PMID: 28504353
    6. Wilm's tumor protein (WT1) bound to 2 WT1 response elements, located at positions -290/-274 and -57/-41 relative to transcription start site. PMID: 27650733
    7. Results suggest that c-mip and RelA define two distinct types of renal damage associated with VEGF-targeted therapies. PMID: 24067439
    8. c-mip has an active role in the podocyte disorders of membranous nephropathy. PMID: 23302718
    9. These results suggest that alterations in NF-kappaB activity might result from the up-regulation of c-mip and are likely to contribute to podocyte disorders in cases of idiopathic nephrotic syndrome. PMID: 22507836
    10. we provide novel evidence that the language-disorder candidate gene CMIP is implicated in reading processes. PMID: 21457949
    11. Eight suggestive significant loci were detected with a series of genes expressed within the inner ear that underlie the auditory function, such as: DCLK1, PTPRD, GRM8, CMIP. PMID: 21493956
    12. results identify c-mip as a key component in the molecular pathogenesis of acquired podocyte diseases PMID: 20484117
    13. Induction of c-mip in Hodgkin-Reed Sternberg cells and podocytes is associated with minimal change nephrotic syndrome in classical Hodgkin lymphoma. PMID: 20200355
    14. results suggest that Tc-mip plays a critical role in Th2 signaling pathway and represents the first proximal signaling protein which links TCR-mediated signal to the activation of c-maf Th2 specific factor PMID: 12939343
    15. Filamin-A interacts with c-mip/Tc-mip in a new T-cell signaling pathway. PMID: 15128042
    16. c-mip inhibits the degradation of I-kappaBalpha and impedes the dissociation of the NF-kappaB/I-kappaBalpha complexes. PMID: 19019440
    17. CMIP modulates phonological short-term memory in language impairment. PMID: 19646677

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturatio
  • 数据库链接：

    HGNC: 24319

    OMIM: 610112

    KEGG: hsa:80790

    STRING: 9606.ENSP00000446100

    UniGene: Hs.594095