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CLPTM1L Antibody

  • 货号：
    CSB-PA850323LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: K562 whole cell lysate
      All lanes: CLPTM1L antibody at 3.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 63, 59 kDa
      Observed band size: 63 kDa
    • IHC image of CSB-PA850323LA01HU diluted at 1:800 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA850323LA01HU diluted at 1:800 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of A549 cells with CSB-PA850323LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CLPTM1L Polyclonal antibody
  • Uniprot No.：
    Q96KA5
  • 基因名：
    CLPTM1L
  • 别名：
    CLPTM1L; CRR9; Cleft lip and palate transmembrane protein 1-like protein; CLPTM1-like protein; Cisplatin resistance-related protein 9; CRR9p
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cleft lip and palate transmembrane protein 1-like protein (32-172AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CLPTM1L Antibody (CSB-PA850323LA01HU)，的标记方式是Non-conjugated。对于CLPTM1L Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA850323LB01HU CLPTM1L Antibody, HRP conjugated ELISA
    FITC CSB-PA850323LC01HU CLPTM1L Antibody, FITC conjugated
    Biotin CSB-PA850323LD01HU CLPTM1L Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Enhances cisplatin-mediated apoptosis, when overexpressed.
  • 基因功能参考文献：
    1. using multivariate logistic regression, we observed that haplotype CLPTM1L is significantly associated with poor treatment response PMID: 29450669
    2. research seems to provide strong evidence for an association between CLPTM1L rs402710C/T and TERT rs2736100A/C SNPs and the risk of OSSC, and suggests that higher tumor RTL values and positive hTERT expression may be applicable as early prognostic markers PMID: 28025427
    3. Homozygous carriers of the CLPTM1L minor C allele presented with faster 6 years telomeres shortening rate compared to carriers of the major allele. PMID: 27532233
    4. Variant in CLPTM1L gene is associated with lung cancer susceptibility. PMID: 28335076
    5. CLPTM1L and TERT have been implicated in cancers, and CIITA is considered as the "master control factor" for the expression of NPC-associated MHC class II genes. These suggested that both SNPs might be functional. Altogether, our findings expand our understanding of the genetic contribution to nasopharyngeal carcinoma (NPC), risk and provide novel biological insights into NPC pathogenesis. PMID: 27436580
    6. A case-control study examined the potential association of 4 CLPTM1L SNPs (rs4975616, rs402710, rs401681, and rs31489) with lung cancer in a Chinese Han population. Minor alleles of all four were significantly associated with decreased lung cancer risk. PMID: 26852039
    7. The data demonstrate that CLPTM1L overexpression can predict poor prognosis in patients with lung cancer and suggest that CLPTM1L might be associated with the regulation of cell migration and invasion. PMID: 27062701
    8. Data suggest that single nucleotide polymorphisms (SNPs) in the telomerase (TERT)-cleft lip and palate transmembrane protein 1-like protein (CLPTM1L) locus may play a role in mediating the susceptibility to nasopharyngeal carcinoma (NPC) in Chinese. PMID: 26621837
    9. CLPTM1L Polymorphism is associated with Nasopharyngeal Carcinoma. PMID: 26545403
    10. This meta-analysis suggests that T allele of CLPTM1L-telomerase reverse transcriptase rs401681 polymorphism is associated with an increased PC risk, especially among Chinese. PMID: 25284078
    11. rs2736100 on TERT-CLPTM1L indicates a poor prognosis for lung cancer in the Chinese Han population. PMID: 25966219
    12. Whole exome sequencing followed by immunohistochemistry of fibrolamellar hepatocellular carcinoma cell lines and tumors showed two structural variants resulting in fusion transcripts: DNAJB1-PRKCA and CLPTM1L-GLIS3. PMID: 25122662
    13. miR-494 regulates cell growth, invasion and apoptosis of esophageal squamous cell carcinoma cells by targeting CLPTM1L. PMID: 25480402
    14. This study showed that genetic variation rs31489 in 5p15.33 was directly associated with the reduced risk of lung cancer in Han Chinese. The CLPTM1L gene rs31489-A allele was a protective factor for the development of lung cancer only in nonsmokers. PMID: 25422207
    15. CLPTM1L-rs401681 polymorphism was not associated with lung cancer risk in Chinese males. PMID: 24861918
    16. Six independent risk neoplasm loci marked by common single-nucleotide polymorphisms have been found: five in the TERT gene, and one in CLPTM1L gene, both on chromosome 5. PMID: 25027329
    17. Polymorphisms of CLPTM1L gene is associated with the risk of hepatocellular carcinoma. PMID: 25339005
    18. association of the CLPTM1L polymorphism and the risk of the lung cancer in non-smoking females in China PMID: 25037574
    19. Using TCGA RNASeq data, we found significantly increased expression of both TERT and CLPTM1L in endometrial cancer tissue compared with normal tissue (TERT P = 1.5 x 10(-18), CLPTM1L P = 1.5 x 10(-19)). PMID: 25487306
    20. TERT-CLPTM1L rs401681 CT and CT/TT genotypes are associated with decreased risk of esophageal squamous cell carcinoma. PMID: 25007268
    21. CLPTM1L polymorphisms did not affect the tumor sensitivity to cisplatin combination chemotherapy in our study patients. PMID: 25155038
    22. consumption of alcohol may interact with CLPTM1L polymorphisms to contribute to overall lung cancer susceptibility. PMID: 25526467
    23. Our meta-analysis provides supportive evidence that CRR9p polymorphism may influence a risk of lung cancer and non-small cell lung cancer in a protective model. PMID: 24957041
    24. CLPTM1L SNPs (rs401681 and rs4975616) were not associated with non-small cell lung cancer in a non-smoking Han Chinese population. PMID: 24175795
    25. CLPTM1L polymorphisms rs402710 and rs401681 are risk-conferring factors for the development of lung cancer. [Meta-analysis] PMID: 24907075
    26. our study indicated that the CLPTM1L - rs401681 (G>A) polymorphism was significantly associated with decreased lung cancer risk, especially among European populations. PMID: 24634236
    27. CLPTM1L SNPs are associated with nasopharyngeal carcinoma risk. PMID: 24615621
    28. the role of TERT-CLPTM1L variants in the etiology of esophageal squamous cell carcinoma and lung cancer PMID: 24386361
    29. CLPTM1L rs31489 was a potential biomarker for lung cancer risk in Caucasians PMID: 24535780
    30. the T allele of rs401681 in CLPTM1L-TERT locus predisposes its carriers to pancreatic cancer. PMID: 24577890
    31. Results suggest that CLPTM1L functions as a growth-promoting gene in the pancreas and that overexpression may lead to an abrogation of normal cytokinesis. PMID: 24648346
    32. A protumorigenic role for CLPTM1L that is critical for Ras-driven lung cancers, with potential implications for therapy and chemosensitization. PMID: 24366883
    33. Genetic variants in TERT and CLPTM1L may affect the susceptibility of lung cancer PMID: 23738012
    34. results suggest that genetic variants in the TERT-CLPTM1L gene may predispose individuals to be susceptible to lung cancer, particularly non-small cell lung cancer, in the Chinese population PMID: 23359026
    35. Polymorphism in CLPTM1L gene is associated with lung cancer. PMID: 23908149
    36. The 5p15.33 locus involving CLPTM1L polymorphisms is significantly associated with lung cancer risk. PMID: 23653681
    37. Our results reiterate that genetic variants of TERT and CLPTM1L contribute to lung cancer susceptibility in Chinese population. PMID: 23433592
    38. TERT-CLPTM1L genomic region was associated with increased risk of cancer. PMID: 23707794
    39. Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism. PMID: 23555636
    40. The 5p15.33 region containing telomerase reverse transcriptase gene (TERT) and cleft lip and palate transmembrane protein 1-like (CLPTM1L) gene showed significant association with lung cancer in Han Chinese. PMID: 23368278
    41. CLPTM1L is a mitochondria protein that may be associated with an anti-apoptotic mechanism which affects drug-resistance in lung cancer cells. PMID: 23300716
    42. TERT-CLPTM1L rs401681[C] allele is risk factor for basal cell carcinoma but not for squamous cell carcinoma. PMID: 22893025
    43. association between genetic polymorphism and cancer risk PMID: 23226346
    44. Further molecular characterization by flow-FISH and quantitative RT-PCR suggest TERT and CLPTM1L as target genes of 5p15.33 rearrangements. PMID: 23137523
    45. The CT genotype at rs401681 was more common and the TT genotype was rare in patients, and the differences were significant between lung adenocarcinoma patients and controls. This was also true for rs402710. Moreover, the frequency of the GGCTCT haplotype was higher and the TTTTTT frequency was lower in patients, especially those with lung adenocarcinoma. PMID: 22370939
    46. haplotype G-T-A in CLPTM1L also confers a risk to glioma suggesting CLPTM1L is also involved in the etiology of glioma. PMID: 22213090
    47. This study implicates anti-apoptotic CLPTM1L function as a potential mechanism of susceptibility to lung tumorigenesis and resistance to chemotherapy. PMID: 22675468
    48. We genotyped eleven SNPs in 2,892 women of African descent but were unable to detect any significant association between TERT-CLPTM1L SNPs and their predispositions for breast cancer risk. PMID: 22134622
    49. the TERT-CLPTM1L locus influences melanoma risk. PMID: 21993562
    50. the lung cancer susceptibility locus Tert-Clptm1l on chromosome 5p15.33 increases the risk for bronchial obstruction and emphysema. PMID: 21622582

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    CLPTM1 family
  • 数据库链接：

    HGNC: 24308

    OMIM: 612585

    KEGG: hsa:81037

    STRING: 9606.ENSP00000313854

    UniGene: Hs.444673