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CLEC4A Antibody

  • 货号：
    CSB-PA181586
  • 规格：
    ￥1100
  • 图片：
    • Gel: 10%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA181586(CLEC4A Antibody) at dilution 1/100 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    Q9UMR7
  • 基因名：
  • 别名：
    C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 6 antibody; C type lectin antibody; C type lectin DDB27 antibody; C type lectin superfamily 6 antibody; C-type (calcium dependent; carbohydrate-recognition domain) lectin; superfamily member 6 antibody; C-type lectin superfamily member 6 antibody; C-type lectin DDB27 antibody; C-type lectin domain family 4 member A antibody; C-type lectin domain family 4; member A antibody; C-type lectin domain family 4; member a2 antibody; C-type lectin superfamily member 6 antibody; CLC4A_HUMAN antibody; Clec4a antibody; Clec4a2 antibody; CLECSF6 antibody; DCIR antibody; Dcir1 antibody; DDB27 antibody; Dendritic cell immunoreceptor antibody; HDCGC13P antibody; Lectin like immunoreceptor antibody; Lectin; C-type; superfamily member 6 antibody; Lectin-like immunoreceptor antibody; LLIR antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human CLEC4A
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.; (Microbial infection) Involved in the interaction between HIV-1 virus and dendritic cells. Enhances HIV-1 binding/entry and virus infection. Requires ITIM motif-associated signal transduction pathway involving phosphatases PTPN6 and PTPN11, SYK, Src kinases and MAP kinases.
  • 基因功能参考文献：
    1. s have determined the structure, tissue distribution, and molecular function of the cartilage-specific lectin CLEC3A and show that CLEC3A binds to plasminogen and participates in tPA-mediated plasminogen activation. PMID: 29146595
    2. DCIR SNP rs2377422 is a novel genetic susceptibility factor for both SLE and primary SS. PMID: 26429306
    3. this study shows that sulfo-Lewis(a) is a high affinity ligand for DCIR and that DCIR interacts with ligands from both pathogenic and endogenous origin of which most are shared by DC-SIGN. PMID: 24239607
    4. No association was found between our inflammatory bowel disease cohort and the candidate single nucleotide polymorphisms for DCIR (CD/HC: P=0.22 and UC/HC: P=0.41) PMID: 22664939
    5. Data provide evidence for association between DCIR rs2377422 and RA in non-Caucasian populations and confirm the influence of DCIR polymorphisms on RA susceptibility, especially on ACPA-negative RA. PMID: 22829930
    6. An involvement of ITIM domain in HIV-1-mediated signaling events and a relationship between phosphorylation events and DCIR function with respect to HIV-1 biology. PMID: 21536857
    7. Data show that antigen targeting via the DCIR receptor allows activation of specific CD8(+) T-cell immunity. PMID: 20530286
    8. CLECSF6 is involved in the control of inflammation in neutrophils PMID: 14550269
    9. The phosphorylation of SHP-2 by GM-CSF promotes the binding of SHP-2 to the GM-CSF receptor to the disadvantage of CLECSF6. PMID: 16360206
    10. Human APLEC and DCIR may be associated with susceptibility to anti-CCP-negative rheumatoid arthritis. PMID: 17665455
    11. The data show that targeting of DCIR can modulate human plasmacytoid dendritic cell function and may be applied in disease prevention and treatment. PMID: 18258799
    12. The mRNA expression from the four known transcripts of DCIR in IFN-gamma-treated human leukocytes together with fine mapping across the locus was analyzed. PMID: 18480830
    13. can participate in the capture of HIV-1 and promote infection in trans and in cis of autologous CD4(+) T cells from human immature monocyte-derived DCs. PMID: 18541725
    14. DCIR as an antigen presenting cell receptor that is endocytosed efficiently in a clathrin-dependent manner and negatively affects TLR8-mediated cytokine production. PMID: 19028959

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein; Extracellular side.
  • 组织特异性：
    Expressed preferentially in hematopoietic tissues. Expressed in all circulating Ag-presenting cells such as dendritic cells, myeloid cells, monocytes, macrophages, B-cells and epidermal Langerhans cells (at protein level). Expressed in peripheral blood le
  • 数据库链接：

    HGNC: 13257

    OMIM: 605306

    KEGG: hsa:50856

    STRING: 9606.ENSP00000229332

    UniGene: Hs.504657