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CIITA Antibody

  • 货号：
    CSB-PA349864
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from K562 cells, using CIITA antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CIITA Polyclonal antibody
  • Uniprot No.：
    P33076
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from internal of Human CIITA.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2. Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion.
  • 基因功能参考文献：
    1. CIITA expression is higher when carried by FP single recombinants than when combined with FPgp or FPenv constructs and can induce HLA-DR cell surface expression. However, in-vivo experiments did not show any significant increase in the humoral response. As CIITA already proved to elicit immunogenicity by improving antigen presentation, further in-vivo experiments should be performed to increase the immune responses PMID: 29385169
    2. Therefore, our data identify HIC1 as a novel factor involved in B cell differentiation acting as an epigenetic repressor of CIITA transcription. PMID: 27720955
    3. Decreasing CIITA expression in allogeneic MSCs abolished MHC II induction during myogenic differentiation and prevented immunorejection of these cells from the infarcted myocardium, which enhanced beneficial functional effects of MSC implantation on myocardial repair. PMID: 27221978
    4. Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (rs7631391), DOCK2 (rs77594147), SLC28A1 (rs28649017), ARHGAP5 (rs7151991), and CIITA (rs45601437) in the Asian comparison. PMID: 28100790
    5. CLPTM1L and TERT have been implicated in cancers, and CIITA is considered as the "master control factor" for the expression of NPC-associated MHC class II genes. These suggested that both SNPs might be functional. Altogether, our findings expand our understanding of the genetic contribution to NPC risk and provide novel biological insights into NPC pathogenesis. PMID: 27436580
    6. When mouse pDCs and CAL-1 cells were stimulated by GM-CSF, mRNA levels of PU.1, pIII-driven CIITA, total CIITA, MHC class II, and the amount of PU.1 binding to pIII were significantly increased PMID: 27105023
    7. the MHC2TA -168 A/G polymorphism is not associated with susceptibility to rheumatoid arthritis in Caucasians [meta-analysis] PMID: 26439834
    8. Observed no association between the MHC2TA or FCRL3 SNPs and rheumatoid arthritis in Mexican patients. PMID: 26350270
    9. CIITA acts as a general restriction factor against HIV-1 not only in T cells but also in myeloid cells. PMID: 27089879
    10. CIITA gene alterations are a common mechanism of immune escape through reduction of MHC class II expression in primary mediastinal large B cell lymphoma. PMID: 26549456
    11. CIITA Isoform III interacts more efficiently with components of the transcription machinery and MHC-II promoter binding proteins. PMID: 26871568
    12. The dimerization region of Epstein-Barr virus Zta is not required to mediate host CIITA repression. PMID: 26653871
    13. Thus, CIITA inhibits cytoplasmic and nuclear steps of human T cell lymphotropic virus type 1 Tax-1-mediated NF-kappaB activation. PMID: 26792751
    14. FOXP1 represents a novel regulator of genes targeted by the class II MHC transactivator CIITA and CD74. PMID: 26500140
    15. Lys(63) ubiquitinated CIITA is concentrated in the cytoplasm and following activation of ERK1/2, CIITA phosphorylation occurs and Lys=ubiquitinated CIITA translocates to the nucleus. PMID: 26181363
    16. Genomic alterations underlying immune privilege in malignant lymphomas prominently include structural genomic changes of the CIITA and CD274 loci. (Review) PMID: 26049756
    17. 19S ATPases have nonproteolytic roles in transcription of CIITApIV genes PMID: 24625964
    18. The negative expression of CIITA protein was the key reason for the loss of MHC II expression in HL60 cells. PMID: 25815463
    19. two DNA-binding proteins, which interact with and regulate PRC2 recruitment to CIITA promoter IV, were identified. PMID: 26283540
    20. mutation results in Mycobacterium avium complex infection PMID: 24789686
    21. Data indicate that the TC+CC genotypes in the MHC class II transactivator gene (MHC2TA) were significantly associated with increased risk of acute coronary syndromes (ACS) as compared to TT genotype. PMID: 25461408
    22. We observed that the CIITA polymorphism rs4774 (+1614G/C) in combination with HLA-DRB1*15:01 increased the OR to 2.65 (p = 0.005). Females carrying both the rs4774*C and DRB1*15:01 alleles had an OR of 4.55 (p = 0.02). PMID: 25992516
    23. our data suggest that adenosine A2b signaling represses CIITA transcription in VSMCs by manipulating the interaction between STAT1 and the epigenetic machinery. PMID: 25765819
    24. PRC2 may inhibit immune surveillance, and it could be targeted to reactivate CIITA expression in SWI/SNF deficient cancers. PMID: 25862816
    25. define the CIITA regulome in B cells and establish sequence specificities that predict activity for an essential regulator of the adaptive immune response PMID: 25753668
    26. our findings support previous data that variability in the CIITA gene affects MS risk, but also that the effect is modulated by MS-associated HLA haplotypes. PMID: 24430172
    27. Sema3A upregulated CIITA expression. Sema3A receptor expression was enhanced by CIITA, establishing a positive feedback loop. Silencing CIITA expression decreases Sema3A-induced CD4+ T-cell proliferation. PMID: 24673430
    28. the presentation of HLA-DQbeta enhanced by LANA knockdown did not help LANA-specific CD4+ T cell recognition of PEL cells, and the inhibition of CIITA by LANA is independent of IL-4 or IFN-gamma signaling PMID: 24204280
    29. genetic polymorphism is associated with endemic pemphigus foliaceus in Brazilian population PMID: 23777927
    30. One-carbon genetic variants influence epigenetic of MHC2TA and RFC1, thus contributing to phenotypic heterogeneity of systemic lupus erythematosus. PMID: 24333266
    31. Two SNPs (rs12932187 and rs11074938) and 2 haplotypes (CIITA_BL1_ht2 and CIITA_BL1_ht5) were demonstrated to be associated with nasal polyps. PMID: 23292525
    32. identification of this novel kinase activity of CIITA further clarifies its role as a functional homolog of TAF1 which may operate during stress and gamma-IFN activated MHC gene transcription PMID: 24036077
    33. Two novel alternatively spliced variants of human interferon gamma-inducible CIITA, one missing exon 7 (CIITADeltaE7), the other with TAG inserted at exon 4/5 junction (CIITA-TAG), were identified and characterized. PMID: 24055710
    34. Human transgenic CIITA-DN (dominant negative) pig cells were evaluated for expression of SLA class II with/without activation, and the human CD4(+) T-cell response to cells from CIITA-DN and wild-type pigs was compared. PMID: 23566228
    35. CIITA -168A-->G promoter single nucleotide polymorphisms are not associated with myasthenia gravis. PMID: 20942939
    36. These results suggest that CIITA transcription is repressed in germinal centre B Diffuse large B-cell lymphoma cells through epigenetic mechanisms PMID: 23789844
    37. Data from this study suggest an association between Oral Lichen Planus and two SNPs (rs4774 and rs6498122)in the CIITA gene in a Chinese sample. PMID: 23489895
    38. MHC2TA 1614 gene polymorphism could be involved in the risk of developing acute coronary syndrome PMID: 23511026
    39. In multiple sclerosis patients, MHC2TA mRNA levels could be decreased by the active replication of HHV-6; the absence of HHV-6 in serum and the increase of MHC2TA expression could be studied as markers of good clinical response to IFN-beta treatment. PMID: 23009575
    40. A significant correlation has been found in the genotype distribution for markers in CIITA (rs11074932 and rs3087456) and the development of type 1 diabetes in the Swedish cohort. PMID: 23052709
    41. Polymorphisms in the inflammatory genes CIITA, CLEC16A and IFNG influence BMD, bone loss and fracture in elderly women PMID: 23133532
    42. The genotypes and allele frequencies distribution of CIITA G-944C were different in the Jinuo, Dai and Aini minority populations. Polymorphism was closely associated with HBsAg carriage. PMID: 21215072
    43. PML is required for efficient IFN-gamma-induced MHC II gene transcription through regulation of the class II transactivator (CIITA) PMID: 23007646
    44. The present study suggests that the MHC2TA polymorphisms are not involved in the risk of developing restenosis after coronary stent placement PMID: 23021357
    45. Our results support involvement of CIITA in RA, but imply that this is population dependent and that the aetiological variant is yet to be discovered. PMID: 22513452
    46. The expressions of CTA and HLA-DR in Jurkat cells remarkably increase after heat shock. PMID: 20078946
    47. ESAT6 could inhibit the expression of type I and type IV CIITA through different pathways PMID: 21670739
    48. The silencing of MHC II molecules in highly metastatic breast cancer cells is associated with distinct epigenetic modifications targeted specifically to the chromatin of CIITApIV. PMID: 22563434
    49. CIITA overexpression can also activate the expression of these genes, indicating that the immunoproteasome genes LMP2 and LMP7 can be activated by both CIITA dependent and CIITA independent pathways PMID: 21989738
    50. IFN-gamma-induced phosphorylation of STAT-1 and transcription of CIITA were suppressed in Kaposi's sarcoma-associated herpesvirus-inoculated endothelial cells via a mechanism involving SOCS3 (suppressor of cytokine signaling 3). PMID: 22532676

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  • 相关疾病：
    Bare lymphocyte syndrome 2 (BLS2)
  • 亚细胞定位：
    Nucleus. Nucleus, PML body. Note=Recruited to PML body by PML.
  • 数据库链接：

    HGNC: 7067

    OMIM: 209920

    KEGG: hsa:4261

    STRING: 9606.ENSP00000316328

    UniGene: Hs.592051