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CHST3 Antibody

  • 货号：
    CSB-PA005409GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q7LGC8
  • 基因名：
    CHST3
  • 别名：
    C6ST 1 antibody; C6ST antibody; C6ST-1 antibody; C6ST1 antibody; Carbohydrate (chondroitin 6) sulfotransferase 3 antibody; Carbohydrate sulfotransferase 3 antibody; Chondroitin 6 O sulfotransferase 1 antibody; Chondroitin 6 sulfotransferase antibody; Chondroitin 6-O-sulfotransferase 1 antibody; Chondroitin 6-sulfotransferase antibody; CHST 3 antibody; Chst3 antibody; CHST3_HUMAN antibody; Galactose/N acetylglucosamine/N acetylglucosamine 6 O sulfotransferase 0 antibody; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0 antibody; GST 0 antibody; GST-0 antibody; GST0 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CHST3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Catalyzes with a lower efficiency the sulfation of Gal residues of keratan sulfate, another glycosaminoglycan. Can also catalyze the sulfation of the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen.
  • 基因功能参考文献：
    1. We describe three consanguineous Indian families with a distinct form of spondyloepiphyseal dysplasia (SED Omani type). It is an autosomal recessive disorder due to mutation in CHST3 gene. PMID: 27753269
    2. A novel CHST3 allele associated with spondyloepiphyseal dysplasia and hearing loss has been described in a consanguineous Pakistani pedigree. PMID: 26572954
    3. Sequencing of CHST3 detected a previously unreported homozygous duplication c.407_426dup (p.Thr143Cysfs*80). The mutation is predicted to lead to frameshift and introduction of a premature stopcodon. PMID: 24300290
    4. expression of CHST3 mRNA was significantly reduced in the intervertebral disc cells of subjects carrying the A allele of rs4148941 PMID: 24216480
    5. The results of this study indicated that the critical period for cortical plasticity is regulated by the 4S/6S ratio of CSPGs, which determines the maturation of parvalbumin-expressing interneurons. PMID: 22246436
    6. Vertebral changes, normal carpal age, lack of facial flattening, and recessive inheritance are characteristic and distinguishes CHST3 deficiency from other disorders with congenital dislocations. PMID: 20830804
    7. report eight CHST3 mutations in six unrelated individuals who presented at birth with congenital joint dislocations PMID: 18513679
    8. Sulfation of the galactose residues in the glycosaminoglycan-protein linkage region by recombinant human chondroitin 6-O-sulfotransferase-1. PMID: 18697746
    9. homozygous missense mutation (T141M) in exon 3 in all three family members with spondyloepiphyseal dysplasia with cardiac involvement PMID: 19320654

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  • 相关疾病：
    Spondyloepiphyseal dysplasia with congenital joint dislocations (SEDCJD)
  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Sulfotransferase 1 family, Gal/GlcNAc/GalNAc subfamily
  • 组织特异性：
    Widely expressed in adult tissues. Expressed in heart, placenta, skeletal muscle and pancreas. Also expressed in various immune tissues such as spleen, lymph node, thymus and appendix.
  • 数据库链接：

    HGNC: 1971

    OMIM: 143095

    KEGG: hsa:9469

    STRING: 9606.ENSP00000362207

    UniGene: Hs.158304