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CCT8 Antibody

  • 货号：
    CSB-PA004873LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate, Raji whole cell lysate, Hela whole cell lysate, HEK293 whole cell lysate, NIH/3T3 whole cell lysate, K562 whole cell lysate
      All lanes: CCT8 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 60, 58, 52 kDa
      Observed band size: 60 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA004873LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA004873LA01HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA004873LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CCT8 Polyclonal antibody
  • Uniprot No.：
    P50990
  • 基因名：
    CCT8
  • 别名：
    CCT8 antibody; C21orf112 antibody; CCTQ antibody; KIAA0002 antibody; T-complex protein 1 subunit theta antibody; TCP-1-theta antibody; CCT-theta antibody; Chaperonin containing T-complex polypeptide 1 subunit 8 antibody; Renal carcinoma antigen NY-REN-15 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human T-complex protein 1 subunit theta protein (224-491AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CCT8 Antibody (CSB-PA004873LA01HU)，的标记方式是Non-conjugated。对于CCT8 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA004873LB01HU CCT8 Antibody, HRP conjugated ELISA
    FITC CSB-PA004873LC01HU CCT8 Antibody, FITC conjugated
    Biotin CSB-PA004873LD01HU CCT8 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
  • 基因功能参考文献：
    1. Study demonstrated that CCT8 expression is widely upregulated in esophageal squamous cell carcinoma (ESCC), and enhanced the migration and invasion of ESCC cells, indicating that ectopic CCT8 expression contributes to the highly aggressive nature of ESCC probably by increasing alpha-actin and beta-tubulin expression. PMID: 29620162
    2. Ectopic expression of CCT8 also ameliorates the age-associated demise of proteostasis and corrects proteostatic deficiencies in worm models of Huntington's disease. PMID: 27892468
    3. data suggest that the GRP94/CCT8/c-Jun/EMT signaling cascade might be a new therapeutic target for HCC PMID: 26718209
    4. showed that high CCT8 protein expression might be related to poor outcome of glioma PMID: 26304164
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    TCP-1 chaperonin family
  • 数据库链接：

    HGNC: 1623

    OMIM: 617786

    KEGG: hsa:10694

    STRING: 9606.ENSP00000286788

    UniGene: Hs.125113