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CCT3 Antibody

  • 货号：
    CSB-PA004857ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: T-complex protein 1 subunit gamma antibody at 12μg/ml + Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 61, 57 kDa
      Observed band size: 61 kDa
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA004857ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA004857ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CCT3 Polyclonal antibody
  • Uniprot No.：
    P49368
  • 基因名：
    CCT3
  • 别名：
    CCT 3 antibody; CCT gamma antibody; CCT-gamma antibody; CCT3 antibody; CCTG antibody; Chaperonin containing TCP1 subunit 3 (gamma) antibody; Chaperonin containing TCP1 subunit 3 antibody; hTRiC5 antibody; PIG48 antibody; T complex protein 1 gamma subunit antibody; T complex protein 1 subunit gamma antibody; T-complex protein 1 subunit gamma antibody; TCP 1 gamma antibody; TCP-1-gamma antibody; TCP1 (t complex 1) ring complex polypeptide 5 antibody; TCPG_HUMAN antibody; TRIC5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human T-complex protein 1 subunit gamma protein (1-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
  • 基因功能参考文献：
    1. Suggest that CCT3 is indispensible for hepatocellular carcinoma cell proliferation, and provides a potential drug target for treatment of HCC. PMID: 26739059
    2. Overexpression of CCT3 in the nuclei of cancerous cells is associated with hepatocellular carcinoma progression. CCT3 may be a target that affects the activation of STAT3 in HCC. PMID: 26229401
    3. Expression of S100A9 and CCTgamma was significantly elevated in liver tissue of patients with cholangiocarcinoma compared with controls. PMID: 23868055
    4. Among ten hepatocellular carcinoma cases with amplicon 1q21-q22, significant gene expression level of JTB, SHC1, CCT3 and COPA in the tumors than the paired adjacent non-malignant liver tissues. PMID: 12586295
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    TCP-1 chaperonin family
  • 数据库链接：

    HGNC: 1616

    OMIM: 600114

    KEGG: hsa:7203

    STRING: 9606.ENSP00000295688

    UniGene: Hs.491494