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CASZ1 Antibody

  • 货号：
    CSB-PA773036LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate
      All lanes: CASZ1 antibody at 4.8μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 191, 125 kDa
      Observed band size: 191 kDa
    • IHC image of CSB-PA773036LA01HU diluted at 1:100 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CASZ1 Polyclonal antibody
  • Uniprot No.：
    Q86V15
  • 基因名：
    CASZ1
  • 别名：
    2410019P08Rik antibody; AV096627 antibody; BC040081 antibody; BOS_15820 antibody; Castor-related protein antibody; CASZ1 antibody; CASZ1_HUMAN antibody; CST antibody; D4Ertd432e antibody; dJ734G22.1 antibody; FLJ12223 antibody; FLJ20321 antibody; MGC155102 antibody; MGC31683 antibody; OTTMUSP00000011746 antibody; OTTMUSP00000011748 antibody; Putative survival-related protein antibody; RP23-230I5.1 antibody; RP4-734G22.2 antibody; SRG antibody; Survival related antibody; Zinc finger protein 693 antibody; Zinc finger protein castor homolog 1 antibody; ZNF693 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Zinc finger protein castor homolog 1 protein (127-266AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CASZ1 Antibody (CSB-PA773036LA01HU)，的标记方式是Non-conjugated。对于CASZ1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA773036LB01HU CASZ1 Antibody, HRP conjugated ELISA
    FITC CSB-PA773036LC01HU CASZ1 Antibody, FITC conjugated
    Biotin CSB-PA773036LD01HU CASZ1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.
  • 基因功能参考文献：
    1. Collectively, our proteomic, biochemical, genetic, and structural studies suggest that the physical interaction between TBX20 and CASZ1 is required for cardiac homeostasis, and further, that reduction or loss of this critical interaction leads to dilated cardiomyopathy (DCM) PMID: 28945738
    2. These findings provide insight into mechanisms by which CASZ1 regulates transcription, and suggests that regulation of CASZ1 subcellular localization may impact its function in normal development and pathologic conditions such as NB tumorigenesis. PMID: 27270431
    3. The current study reveals CASZ1 as a new gene responsible for human dilated cardiomyopathy (DCM), which provides novel mechanistic insight and potential therapeutic target for CASZ1-associated DCM, implying potential implications in improved prophylactic and therapeutic strategies for DCM, the most common type of primary myocardial disease. PMID: 28099117
    4. the current study firstly identifies CASZ1 as a new gene predisposing to congenital heart disease in humans PMID: 27693370
    5. CASZ1b binds to chromatin and recruits NuRD complexes to orchestrate epigenetic-mediated transcriptional programs PMID: 26296975
    6. CASZ1 inhibits cell cycle progression in neuroblastoma by restoring retinoblastoma protein activity. PMID: 23892435
    7. Papillomavirus DNA integration is associated with loss of CASZ1 gene and thus cervical carcinogenesis. PMID: 22262398
    8. This study identifies key domains needed for CASZ1b to regulate gene transcription; a link between loss of CASZ1b transcriptional activity and attenuation of CASZ1b-mediated inhibition of neuroblastoma growth and tumorigenicity PMID: 22331471
    9. determined that the tumor suppressors CLU, NGFR, and RUNX3 were also directly repressed by EZH2 like CASZ1 in NB cells PMID: 22068036
    10. CASZ1 is a critical modulator of neural cell development, and that somatically acquired disruption of normal CASZ1 expression contributes to the malignant phenotype of human Neuroblastoma. PMID: 21252912
    11. The study indicates that although their mechanisms of regulation may be distinct, both CASZ1b and CASZ1a have largely redundant but critical roles in suppressing tumor cell growth. PMID: 21490919
    12. CASZ1 is expressed in a number of human tumors and localizes to a chromosomal region frequently lost in tumors of neuroectodermal origin. PMID: 16631614

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in heart, lung, skeletal muscle, pancreas, testis, small intestine, and stomach, but it is not detectable in the adult brain.
  • 数据库链接：

    HGNC: 26002

    OMIM: 609895

    KEGG: hsa:54897

    STRING: 9606.ENSP00000366221

    UniGene: Hs.439894