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BHLHA15 Antibody

  • 货号：
    CSB-PA755911LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA755911LA01HU diluted at 1:150 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) BHLHA15 Polyclonal antibody
  • Uniprot No.：
    Q7RTS1
  • 基因名：
    BHLHA15
  • 别名：
    Basic helix loop helix domain containing class B 8 antibody; Basic helix loop helix family member a15 antibody; BHA15_HUMAN antibody; Bhlha15 antibody; bHLHB8 antibody; Class A basic helix-loop-helix protein 15 antibody; Class B basic helix-loop-helix protein 8 antibody; Class II bHLH protein MIST1 antibody; intestine and stomach expression 1 antibody; MIST 1 antibody; MIST-1 antibody; MIST1 antibody; Muscle antibody; Muscle intestine and stomach expression 1 antibody; protein MIST1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Class A basic helix-loop-helix protein 15 protein (2-72AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，BHLHA15 Antibody (CSB-PA755911LA01HU)，的标记方式是Non-conjugated。对于BHLHA15 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA755911LB01HU BHLHA15 Antibody, HRP conjugated ELISA
    FITC CSB-PA755911LC01HU BHLHA15 Antibody, FITC conjugated
    Biotin CSB-PA755911LD01HU BHLHA15 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3'.
  • 基因功能参考文献：
    1. noted a higher mean value of microvascular density in CK5/6 and Ep-CAM-immunopositive tumors, carcinomas with aberrant CK8/18 expression, and carcinomas with no or strong expression of MMP-2 in stromal fibroblast-like cells PMID: 22495370
    2. Activation of protein kinase Cdelta leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1. PMID: 22374815
    3. Chief cells emerge from the Mist. PMID: 21907708
    4. MIST1 is enriched upon plasma cell differentiation. PMID: 21098683
    5. Our findings implicate MIST1 as a reliable marker of mature, healthy chief cells, and we provide the first evidence that metaplasia in humans arises at least in part from the chief cell lineage. PMID: 20709804
    6. MIST1 binds to highly conserved CATATG E-boxes to directly activate transcription of 6 genes, including those encoding the small GTPases RAB26 and RAB3D. PMID: 20038531
    7. Mist1 within the hierarchy of known helix-loop-helix/basic helix-loop-helix proteins that control mammary epithelial cell development PMID: 16645041

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in brain, liver, spleen and skeletal muscle.
  • 数据库链接：

    HGNC: 22265

    OMIM: 608606

    KEGG: hsa:168620

    STRING: 9606.ENSP00000326391

    UniGene: Hs.511979