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  4. BGLAP Antibody

BGLAP Antibody

  • 货号：
    CSB-PA135204
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA135204(BGLAP Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA135204(BGLAP Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P02818
  • 基因名：
    BGLAP
  • 别名：
    BGLAP antibody; BGP antibody; Bone gamma carboxyglutamate (gla) protein antibody; Bone gamma carboxyglutamate gla protein osteocalcin antibody; Bone gamma carboxyglutamate protein antibody; Bone Gla protein antibody; Gamma carboxyglutamic acid containing protein antibody; Gamma-carboxyglutamic acid-containing protein antibody; OC antibody; OCN antibody; OSTCN_HUMAN antibody; Osteocalcin antibody; OTTHUMP00000016586 antibody; PMF1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human BGLAP
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
  • 基因功能参考文献：
    1. The results of this study suggest that serum osteocalcin is associated with the onset of puberty in girls. PMID: 30089739
    2. The correlation between Mycobacterium avium subsp. paratuberculosis (MAP) infection and elevation of sera ucOC, reduction of active osteocalcin and increased calcium supports MAP infection role in Crohn's disease and complications with osteoporosis. PMID: 29638140
    3. The results showed no significant correlation between osteocalcin HindIII gene polymorphism and bone mineral density (BMD) and therefore osteocalcin HindIII gene polymorphism may not have major effects on BMD variation in postmenopausal North Indian women. PMID: 30179426
    4. Decreased circulating carboxylated osteocalcin is associated with low-energy bone fractures in children. PMID: 29882816
    5. a decrease in serum osteocalcin levels is associated with future development of type 2 diabetes mellitus. PMID: 28766135
    6. Findings from the available data indicated an overall significant inverse association between serum osteocalcin and body mass index--{REVIEW} PMID: 28822067
    7. relatively lower serum osteocalcin levels were associated with a higher risk of MACE in Chinese men with CAD PMID: 28921598
    8. undercarboxylated form of osteocalcin in serum not related significantly to semen parameters or measured hormones in male infertility PMID: 28000970
    9. serum level not correlated with gender, race/ethnicity, age, diabetes type, BMI percentile, random C-peptide, glucose, or HbA1c at pediatric diabetes diagnosis; serum level inversely correlated with HbA1c at first office visit following diagnosis PMID: 28093839
    10. Serum osteocalcin was directly and independently correlated with circulating uric acid in a population of healthy obese subjects. PMID: 28847266
    11. gamma-carboxylation of OCN on Glu17 residue correlates with insulin resistance and subclinical inflammation, suggesting that gamma-carboxylation of OCN negatively regulates its endocrine action PMID: 28242268
    12. There were differences in the associations between total osteocalcin and glucose metabolism in Han and Uygur T2DM patients, indicating genetic factors may play a role in modulating OC and glucose metabolism in different ethnic population. PMID: 28732499
    13. The study demonstrated that undercarboxylated osteocalcin (ucOC) is related to 25(OH)D and adiponectin concentrations. Both ucOC and 25(OH)D were lower in overweight and obese adolescents. PMID: 28443718
    14. Increased advanced glycation end products and protein oxidative damage markers in the course of obesity may contribute to decreased carboxylated osteocalcin serum level. PMID: 28841723
    15. Progressive calcification of atherosclerotic plaques is accompanied by insignificant accumulation of calcitonin and osteoprotegerin, whereas the osteocalcin expression significantly increased during calcification. PMID: 28429221
    16. Undercarboxylated osteocalcin reflects the reserve capacity of beta-cell function, such as the bolus insulin secretion ability in patients with type 2 diabetes. PMID: 27889949
    17. XPS showed that similar amounts of hOC and dhOC were absorbed onto hydroxyapaptite and octacalcium phosphate surfaces, but ToF-SIMS detected some small differences in the amino acid fragment intensities on these surfaces for adsorbed hOC and dhOC. PMID: 28521505
    18. Common polymorphism rs1800247 in osteocalcin gene was associated with hypertension and diastolic blood pressure levels. The association of rs1800247 with hypertension was affected by its interaction with HOMA-IR. PMID: 27251081
    19. These findings indicate the undercarboxylated form of OC is not implicated in age-related changes in skeletal muscle or adipose tissue mass in older community-dwelling adults. PMID: 27604070
    20. Demonstrate a positive association between osteocalcin, a factor known to regulate bone remodelling, with cognitive performance in older non-demented women. PMID: 27515675
    21. Common genetic variants of the osteocalcin gene may not be a major contributor to variations in serum osteocalcin or BMD in postmenopausal and elderly Chinese women. PMID: 28002816
    22. Several detected relations between OCN and metabolites were strongly linked to renal function, however, a number of associations remained significant after adjustment for renal function. Intermediates of proline catabolism were associated with OCN reflecting the implication in bone metabolism. PMID: 28922389
    23. Low serum osteocalcin concentrations are associated with type 2 diabetes. PMID: 27061949
    24. Decreased blood concentration of Carboxylated osteocalcin is associated with metabolic complications and inflammation. PMID: 27667744
    25. Total and undercarboxylated osteocalcin levels were significantly correlated with insulin secretion and insulin resistance indices, but not adiponectin levels, in pregnant women. PMID: 26708046
    26. Osteocalcin and Sex Hormone Binding Globulin Compete on a Specific Binding Site of GPRC6A. PMID: 27673554
    27. Osteocalcin plays an essential role for the maturation of mineral species and modulates osteogenic differentiation of mesenchymal stromal cells (MSCs). PMID: 28106724
    28. Serum osteocalcin levels in pediatric obstructive sleep apnea hypopnea syndrome patients were significantly lower than normal controls before adenotonsillectomy. PMID: 26938749
    29. the relationship between serum osteocalcin and glucose metabolism parameters in liver transplantation recipients, was examined. PMID: 26743527
    30. Reduced plasma Osteocalcin levels are associated with cardiovascular and metabolic diseases. PMID: 26863345
    31. An overview of osteocalcin progress. PMID: 26747614
    32. the BMP-2/Smad1/5/RUNX2 signaling pathway participates in the silicon-mediated induction of COL-1 and osteocalcin synth PMID: 27025722
    33. Data indicate that lower osteocalcin was an independent predictor of worse cognitive performance on multivariate analysis. PMID: 26406918
    34. A common polymorphism rs1800247 in osteocalcin gene may effect the risk of osteoporosis and fracture and serum osteocalcin levels in Chinese. PMID: 26194493
    35. There is an inverse relationship between the visfatin and undercarboxylated osteocalcin in type 2 diabetes patients with diabetic kidney disease. PMID: 26922969
    36. This study investigated osteocalcin, metabolic parameters and anthropometric characteristics in normal weight and overweight/obese children. PMID: 26772621
    37. Nonalcoholic fatty liver disease negatively associated with right-hip bone mineral density and serum osteocalcin in Korean men. PMID: 26636404
    38. The aims of this study were to evaluate OCN and sclerostin levels in subjects who underwent coronary artery bypass graft (CABG) surgery compared with those in normal controls. PMID: 26576474
    39. serum level not associated with weight loss or body fat percentage PMID: 25963022
    40. Serum osteocalcin levels are inversely correlated with nonalcoholic fatty liver disease in postmenopausal Chinese women with normal blood glucose levels. PMID: 26567728
    41. Serum total osteocalcin level is significantly lower in 2 diabetes mellitus patients than controls. PMID: 26372899
    42. Elevated serum preptin and decreased osteocalcin concentrations, together with insulin resistance, are associated with obesity and overweight. PMID: 25675353
    43. gestational diabetes is not associated with osteocalcin, under-carboxylated osteocalin, osteopontin and leptin and does not correlate with insulin resistance. PMID: 25480426
    44. Serum uOC levels in non-dialysis patients with CKD are significantly lower than those in healthy individuals, and uOC is closely associated with subclinical atherosclerosis in CKD patients. PMID: 26381729
    45. Endocrine function of osteocalcin and the cell biology events that allow osteocalcin to become a hormone. [review] PMID: 25577163
    46. Data indicate that higher osteocalcin (OC) or its undercarboxylated form (ucOC) concentration and ucOC to osteocalcin ratio (OCR) were associated with the risk of coronary calcification in men. PMID: 25868823
    47. Data suggest that a low serum osteocalcin level was an independent risk factor for abdominal obesity. PMID: 25871789
    48. Correlation between osteocalcin-positive endothelial progenitor cells and spotty calcification in patients with coronary artery disease PMID: 25644945
    49. These findings unequivocally document that increased vitamin K intake reduces the uncarboxylated form of OCN PMID: 25855755
    50. Serum osteocalcin level was not independently associated with C-IMT in a metabolically healthy Chinese population. PMID: 26077201

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Osteocalcin/matrix Gla protein family
  • 数据库链接：

    HGNC: 1043

    OMIM: 112260

    KEGG: hsa:632

    STRING: 9606.ENSP00000357255

    UniGene: Hs.654541