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BCLAF1 Antibody

  • 货号：
    CSB-PA001060
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of A549 cells using BTF Polyclonal Antibody
    • Western Blot analysis of NIH-3T3 cells using BTF Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9NYF8
  • 基因名：
  • 别名：
    Bcl 2 associated transcription factor antibody; Bcl-2-associated transcription factor 1 antibody; BCL2 associated transcription factor 1 antibody; BCLAF1 antibody; BCLF1_HUMAN antibody; bK211L9.1 antibody; Btf antibody; KIAA0164 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human BTF.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
  • 基因功能参考文献：
    1. LTBR and BCLAF1 showed higher DNA methylation percentages in the marsupialized OKCs, but this difference did not affect gene expression (P > .05). PMID: 28864293
    2. Results indicate a role for the RNA processing factors THRAP3 and BCLAF1 in the regulation of the cellular DNA damage response (DDR) pathway. PMID: 29112714
    3. findings link treatment responsiveness to re-instatement of miR-194-5p/BCLAF1 balance PMID: 28216661
    4. SMYD3 physically interacts with the promoter of BCLAF1 and upregulates its expression by accumulating di- and trimethylation of H3K4 at the BCLAF1 locus. BCLAF1 depletion inhibits SMYD3-induced autophagy. PMID: 26676636
    5. The Bclaf1 can interact with the leucine zipper region of C/EBPbeta and cooperate with C/EBPbeta to upregulate IL-8. PMID: 26794446
    6. both cytoplasmic BCLAF1 expression and nuclear BCLAF1 expression are increased in post-neoadjuvant therapy rectal cancer, and that negative and weak nuclear BCLAF1 expression are independently associated with a poor prognosis PMID: 26183150
    7. SRSF10 is a key regulator of BCLAF1 pre-mRNA splicing and the maintenance of oncogenic features in human colon cancer cells PMID: 25091051
    8. BTF has functions distinct from TRAP150 in regulating the subcellular distribution of mRNAs in human cells. PMID: 23778535
    9. BCLAF1 co-localized with gammaH2AX foci in nuclei and stabilized the Ku70/DNA-PKcs complex therein, facilitating non-homologous end joining (NHEJ)-based DSB repair in surviving cells. PMID: 22833098
    10. In the absence of BclAF1 neutralization, viral gene expression and replication are inhibited. These data identify two temporally and mechanistically distinct functions used by human cytomegalovirus to down-regulate a cellular antiviral protein PMID: 22645331
    11. Sirt1 negatively regulates T cell activation via H3K56 deacetylation at the promoter region to inhibit transcription of Bclaf1 PMID: 21454709
    12. Findings indicate a role for BCLAF1 in post-transcriptional processes that impact mRNA metabolism. PMID: 20661537
    13. Two-dimensional differential in-gel electrophoresis (2D-DIGE) revealed the differential expression of 51 proteins in response to C16-ceramide. Cell death-promoting factor Btf was found to be implicated in the apoptotic signal triggered by ceramide. PMID: 19705920
    14. These results suggest that Btf localization is regulated by apoptotic signals, and that loss of emerin binding to Btf may be relevant to muscle wasting in Emery-Dreifuss muscular dystrophy. PMID: 15009215
    15. These findings provide evidence that activation of TP53 gene transcription by PKCdelta triggers TP53-dependent apoptosis in response to DNA damage. PMID: 17938203

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Nucleus speckle. Nucleus, nucleoplasm.
  • 蛋白家族：
    BCLAF1/THRAP3 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 16863

    OMIM: 612588

    KEGG: hsa:9774

    STRING: 9606.ENSP00000435210

    UniGene: Hs.486542