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BANP Antibody

  • 货号：
    CSB-PA002555GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8N9N5
  • 基因名：
    BANP
  • 别名：
    AAH09424 antibody; Banp antibody; BANP_HUMAN antibody; BEN domain-containing protein 1 antibody; BEND1 antibody; BTG3 associated nuclear protein isoform a antibody; Btg3-associated nuclear protein antibody; DKFZp761H172 antibody; FLJ 10177 antibody; FLJ 20538 antibody; FLJ10177 antibody; FLJ20538 antibody; Protein BANP antibody; Scaffold/Matrix associated region 1 antibody; Scaffold/matrix-associated region-1-binding protein antibody; SMAR 1 antibody; SMAR1 antibody; SMARBP 1 antibody; SMARBP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human BANP
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest.
  • 基因功能参考文献：
    1. Cdc20 functions as an important negative regulator of SMAR1 in higher grades of cancer PMID: 28617439
    2. Dysregulated circ-BANP appears to have an important role in colorectal cancer cells. PMID: 28103507
    3. results reveal the complex molecular mechanism underlying SMAR1-mediated signal-dependent and -independent regulation of alternative splicing via Sam68 deacetylation PMID: 26080397
    4. SMAR1-mediated regulation of repair and apoptosis via a complex crosstalk involving Ku70, HDAC6 and Bax. PMID: 25299772
    5. Data indicate the role of SMAR1 protein in NF-kappaappa B dependent transcriptional regulation of pro-angiogenic chemokine interleukin-8 (IL-8). PMID: 25239884
    6. indicate a crucial role for SMAR1 in restraining breast cancer cell migration and suggest the candidature of this scaffold matrix-associated region-binding protein as a tumor suppressor. PMID: 25086032
    7. SMAR1 has a role in repressing c-Fos-mediated HPV18 E6 transcription through alteration of chromatin histone deacetylation PMID: 25157104
    8. During hemin-induced erythroid differentiation, enhanced expression of SMAR1 negatively correlates with miR-320a expression. PMID: 23876508
    9. TCF-4, beta-catenin, and SMAR1 tether at the -143-nucleotide site on the HIV LTR to inhibit HIV promoter activity. PMID: 22674979
    10. Results indicate that SMAR1 is an important player in p300-p53 regulated DNA damage signalling pathway and can exert its effect on apoptosis in a transcription independent manner. PMID: 22074660
    11. multiple roles of nuclear matrix associated protein SMAR1 in regulating various cellular target genes involved in cell growth, apoptosis and tumorigenesis.(REVIEW) PMID: 20709157
    12. A novel mechanism of regulation of oxidative stress by ATM through modulation of SMAR1-AKR1a4 complex, is proposed. PMID: 20097305
    13. SMAR1 plays a central role in coordinating p53 and TGFbeta pathways in human breast cancer. PMID: 17668048
    14. report Prostaglandin A2 (PGA2) induced binding of HSP70 to a novel site on phi1 SMAR1 5' UTR which stabilizes the wild type transcript and leads to subsequent increase in SMAR1 protein levels. PMID: 20153327
    15. On mild DNA damage, SMAR1 selectively represses BAX and PUMA through binding to the MAR independently of inducing p53 deacetylation through HDAC1. PMID: 20075864
    16. Human breast cancer tissue sections that showed reduced SMAR1 expression exhibited increased surface roughness. PMID: 19799771
    17. SMAR1 plays an important role in the regulation of T cell development as well as V(D)J recombination PMID: 15623522
    18. SMAR1 regulates cyclin D1 by modification of chromatin through the SIN3/histone deacetylase 1 complex PMID: 16166625
    19. tumor suppressor SMAR1 downregulates Cytokeratin 8 gene expression by modulating p53-mediated transactivation of this gene PMID: 18822384
    20. tumor suppressor protein SMAR1 can modulate NF-kappaB transactivation and inhibit tumorigenesis by regulating NF-kappaB target genes PMID: 18981184
    21. Results highlight the role of SMAR1 in masking the active phosphorylation site of p53, enabling the deacetylation of p53 by HDAC1-MDM2 complex, thereby regulating the p53 transcriptional response during stress rescue. PMID: 19303885
    22. Identification of a novel mouse MAR-binding protein, named SMAR1, which shares homology with SATB1 and Cux in the MAR-binding domain/Cut repeat and also with the tetramerization domain of a B cell-specific MAR-binding protein, Bright. PMID: 10950932

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BANP/SMAR1 family
  • 组织特异性：
    Down-regulated in breast cancer cell lines.
  • 数据库链接：

    HGNC: 13450

    OMIM: 611564

    KEGG: hsa:54971

    STRING: 9606.ENSP00000286122

    UniGene: Hs.461705