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B2m Antibody

  • 货号：
    CSB-PA002486LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse spleen tissue, Mouse stomach tissue
      All lanes: B2m antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 14 kDa
      Observed band size: 14 kDa
    • IHC image of CSB-PA002486LA01MO diluted at 1:400 and staining in paraffin-embedded mouse lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) B2m Polyclonal antibody
  • Uniprot No.：
    P01887
  • 基因名：
  • 别名：
    B2mBeta-2-microglobulin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse
  • 免疫原：
    Recombinant Mouse Beta-2-microglobulin protein (21-119AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，B2m Antibody (CSB-PA002486LA01MO)，的标记方式是Non-conjugated。对于B2m Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA002486LB01MO B2m Antibody, HRP conjugated ELISA
    FITC CSB-PA002486LC01MO B2m Antibody, FITC conjugated
    Biotin CSB-PA002486LD01MO B2m Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
  • 基因功能参考文献：
    1. When no programmed delay interval was imposed, the beta2m-deficient mice acquired the task as fast as controls, suggesting that discrimination of left and right positions is not impaired by the total loss of hippocampal asymmetry. beta2m-deficient mice made fewer correct responses than control mice when variable delay was imposed, suggesting that the asymmetry of hippocampal circuitry plays an important role in working... PMID: 28039089
    2. The results show that, although other factors influence the fibril growth kinetics, a striking difference in the solubility of the proteins is a key determinant of the different amyloidogenicity of human B2M and mouse B2M. PMID: 26780548
    3. Use of shRNA against beta-2-microglobulin offers a simple and effective approach to minimize immunogenicity of the main cellular components of cardiac tissue constructs in non-syngeneic recipients. PMID: 25775354
    4. systemic B2M accumulation in aging blood promotes age-related cognitive dysfunction and impairs neurogenesis PMID: 26147761
    5. Because all forms of H-2K(b) are internalized but little beta2m-receptive heavy chain is present at the cell surface, it is likely that beta2m dissociation and recognition of the heavy chain for lysosomal degradation take place in an endocytic compartment. PMID: 25782992
    6. We report a novel dichotomous role of beta2m and CD1d, whereby these molecules differently regulate autoimmunity against phospholipid versus non-phospholipid autoantigens. PMID: 23531237
    7. The goal of the present work was to study peculiarities in functioning of proteasomes and associated signaling pathways along with evaluation of NeuN and gFAP expression in different sections of the brain in mice. PMID: 24237146
    8. MHC I and b2m genes are both expressed in in human as well as mice during the developmental stages of cerebellar cortex PMID: 24272393
    9. Knocking out beta 2 microglobulin abolishes NMDAR-dependent LTD in area CA1 of adult mouse hippocampus and is accompanied by memory deficits. MHC class I expression could be an unexpected cause of disrupted synaptic plasticity and cognitive deficits. PMID: 23959708
    10. This study demonistrated that Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis PMID: 22335434
    11. Data show that tapasin expression is enhanced by beta 2-microglobulin via both transcriptional and post-transcriptional mechanisms. PMID: 23089196
    12. This gene is known to be important for immune responses and may potentially regulate alcohol consumption. PMID: 21309947
    13. Data show that NK subsets bearing Ly49s, which bind "self-MHC" were found to be the dominant subset responsible for beta2m(-/-) BMC rejection. PMID: 22184406
    14. Skin graft rejection induced by B2m-derived minor transplantation antigens involves Th2-dependent eosinophilic rejection, IFN-gamma dependent mechanisms, and Fas-Fas ligand interactions. PMID: 12077281
    15. beta-2 microglobulin knockout-anti-asialoGM1 mice exhibit improved hemodynamics and cardiac contractile function after cecal ligation and puncture that may account, in part, for survival benefit PMID: 14630624
    16. Rag1 deficiency in Hfe knock-out mice leads to heightened iron overload, mainly in the liver, whereas the heart and pancreas are relatively spared compared with beta2mRag1(-/-) mice. PMID: 14656877
    17. Beta 2 microglobulin deficient mice react normally to endotoxin and their hepatocytes react normally to IL-6. PMID: 15192150
    18. Results show that a seven-residue segment of human beta2-microglobulin (beta2M), not found in mouse beta2M, is sufficient to convert beta2M to the amyloid state, and that specific residue interactions are crucial to the conversion. PMID: 15249659
    19. Knockout mice represent an instructive model of spontaneous iron overload resembling genetic hemochromatosis. PMID: 15315790
    20. Experimental autoimmune encephalomyelitis in beta 2-microglobulin(beta2m)-deficient mice is significantly more severe, with a 10-fold increased mortality in beta2m-null mice as compared to wild-type C57BL/6 mice. PMID: 15837577
    21. The results suggested that beta2m as well as TAP was necessary for the transportation of blastocyst MHC from endoplasmic reticulum to cell surfaces through the Golgi apparatus, similar to other MHC class I molecules. PMID: 15896332
    22. thermodynamic stabilities of the beta2m variants PMID: 16229893
    23. Data provide a crystallographic comparison of H-2D(b) in complex with gp33 peptide and either human or mouse beta(2)microglobulin. PMID: 16375919
    24. acquisition of an impaired breeding phenotype (IBP) as a result of the knockout of beta-2 microglobulin (B2M) directly implicates B2M in the reproductive cycle of mice PMID: 17442853
    25. voluntary wheel running exercise-induced liver beta2-microglobulin expression is related to lower IgG clearance in the blood PMID: 17524613
    26. macrophages have a role in the formation and degradation of beta2-microglobulin amyloid fibrils PMID: 17686767
    27. Alterations in beta 2-microglobulin influence the ability of T cell receptors to engage class-I histocompatibility antigen H-2Kb during normal T cell physiology. PMID: 17785793
    28. beta 2m-associated effect other than FcRn prolongs the survival of both IgG and albumin PMID: 18375831
    29. Data show that cerebella from adult mice deficient for H2-D1 and H2-K1, and for beta2-microglobulin gene are of deficient elimination of supernumerary climbing fiber synapses on their Purkinje cells. PMID: 18418877
    30. A natural killer T (NKT) cell subset is restricted by a beta-2 microglobulin-independent form of CD1d antigen and may induce bronchial hyperreactivity. PMID: 18802058
    31. these studies clearly indicate the importance of a beta(2)-microglobulin-dependent but CD8 T-cell- and iNK T-cell-independent mechanism critical for survival during K. pneumoniae bacteremia. PMID: 18981251
    32. the mechanism by which beta(2)-microglobulin negatively regulates gammadelta T cell homeostasis remains to be determined PMID: 19201842
    33. results indicate that beta(2)m may be involved in proliferation of uNK cells in the metrial gland, and that beta(2)m may affect the maturation of uNK cells in the decidua basalis. PMID: 19262044
    34. NKT cells modulate plasmid DNA vaccine antigen expression and vaccine-elicited immune responses by MCP-1 secretion after interaction with a beta2-microglobulin-independent CD1d PMID: 19833737

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Beta-2-microglobulin family
  • 数据库链接：

    KEGG: mmu:12010

    STRING: 10090.ENSMUSP00000099534

    UniGene: Mm.163