Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. Acta1 Antibody

Acta1 Antibody

  • 货号：
    CSB-PA00750E0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Acta1 antibody at 2µg/ml
      Lane 1: Mouse brain tissue
      Lane 2: Mouse lung tissue
      Lane 3: Rat muscle tissue
      Lane 4: Zebrafish lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 43 kDa
      Observed band size: 43 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Acta1 Polyclonal antibody
  • Uniprot No.：
    P68134
  • 基因名：
    Acta1
  • 别名：
    Acta1 antibody; ActaActin antibody; alpha skeletal muscle antibody; Alpha-actin-1) [Cleaved into: Actin antibody; alpha skeletal muscle antibody; intermediate form] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse, Rat, Zebrafish
  • 免疫原：
    Mouse Actin, alpha skeletal muscle (Native Protein)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Acta1 Antibody (CSB-PA00750E0Rb)，的标记方式是Non-conjugated。对于Acta1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA00750F0Rb Acta1 Antibody, HRP conjugated ELISA
    FITC CSB-PA00750G0Rb Acta1 Antibody, FITC conjugated
    Biotin CSB-PA00750H0Rb Acta1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
  • 基因功能参考文献：
    1. alpha smooth muscle actin (alphaSMA) was identified as a marker of osteoprogenitor cells in bone and periodontium. PMID: 26721734
    2. WIP is a link between membrane lipid composition and actin cytoskeleton at dendritic spines. PMID: 24698977
    3. ACTA1(Asp286Gly) mouse model of nemaline myopathy provide evidence of impaired in vivo muscle function, altered muscle structure and disturbed energy metabolism. PMID: 23977274
    4. Combined MRI and (3)(1)P-MRS investigations of the ACTA1(H40Y) mouse model of nemaline myopathy show impaired muscle function and altered energy metabolism. PMID: 23613869
    5. Data indicate roles for linkers of nucleus to cytoskeleton (LINC) molecules nesprin2giant and nesprin3, which anchor actin cap fibers to the nucleus. PMID: 23336069
    6. Asp286Gly acts as a "poison-protein" and according to the computational analysis it modifies the actin-actin interface. This phenomenon is likely to prevent proper myosin cross-bridge binding. PMID: 23029319
    7. Data show that upon actin binding, the two domains of utrophin become dramatically separated and ordered, indicating a transition to a single open and extended conformation. PMID: 21768337
    8. Data indicated that CacyBP/SIP could simultaneously interact with tubulin and actin, suggesting that CacyBP/SIP might link actin and tubulin cytoskeletons. PMID: 20637809
    9. Results provide the genetic proof that platelet production from megakaryocytes strictly requires dynamic changes in the actin cytoskeleton. PMID: 20530287
    10. Data show that while increases in cardiac and vascular smooth-muscle actin can partially compensate for the lack of skeletal actin in null mice, this is not sufficient to support adequate skeletal muscle growth and/or function. PMID: 12138199
    11. alpha-skeletal-muscle actin mutations have roles in development of myopathies PMID: 15226407
    12. myotome pairs are transiently left-right asymmetric, with higher expression of alpha-skeletal actin and myosin light chain 3F (MLC3F) on the left side between embryonic day 9.5-10.25. PMID: 15499557
    13. K+-depolarization increased Tnni1 and Acta1 mRNA levels in both differentiated C2C12 and rat skeletal muscle cells in primary culture PMID: 17146758
    14. Myotubes are a suitable system to study the capacity of a mutant to incorporate into actin structures or to form or induce pathological changes. PMID: 17227580
    15. Val163Met mutation in alpha-skeletal actin can affect the dynamics of other actin isoforms and severely disrupt sarcomeric structure, processes that can contribute to muscle weakness. PMID: 17705262
    16. F- and G-actin concentrations in lamellipodia are about 500 microM & 150 microM, respectively. The excess of G-actin shows that the polymerization rate is not limited by diffusion & is tightly controlled by polymerization/depolymerization modulators. PMID: 19277198

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Actin family
  • 数据库链接：

    KEGG: mmu:11459

    STRING: 10090.ENSMUSP00000034453

    UniGene: Mm.214950