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ARHGAP29 Antibody

  • 货号：
    CSB-PA681475LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ARHGAP29 Polyclonal antibody
  • Uniprot No.：
    Q52LW3
  • 基因名：
    ARHGAP29
  • 别名：
    ARHGAP 29 antibody; Arhgap29 antibody; ARHGAP29 protein antibody; MGC166097 antibody; PARG 1 antibody; PARG1 antibody; PTPL1 associated RhoGAP 1 antibody; PTPL1-associated RhoGAP protein 1 antibody; RHG29_HUMAN antibody; Rho GTPase activating protein 29 antibody; Rho GTPase activating protein 29 isoform CRA_a antibody; Rho GTPase activating protein 29 isoform CRA_b antibody; Rho GTPase-activating protein 29 antibody; Rho-type GTPase-activating protein 29 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Rho GTPase-activating protein 29 protein (161-392AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ARHGAP29 Antibody (CSB-PA681475LA01HU)，的标记方式是Non-conjugated。对于ARHGAP29 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA681475LB01HU ARHGAP29 Antibody, HRP conjugated ELISA
    FITC CSB-PA681475LC01HU ARHGAP29 Antibody, FITC conjugated
    Biotin CSB-PA681475LD01HU ARHGAP29 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.
  • 基因功能参考文献：
    1. Risk haplotypes affect ARHGAP29 expression causing non-syndromic orofacial clefting. PMID: 28287101
    2. The variant in question segregates as an autosomal dominant trait caused by an heterozygous missense variant in ARHGAP29 (p.Ser552Pro) that had not previously been identified in a population genomic databases. The p.Ser552Pro ARHGAP29 variant was not present in genomic databases and was predicted to be pathogenic by multiple in silico programs. PMID: 28029220
    3. YAP promotes the expression of ARHGAP29 to suppress the RhoA-LIMK-cofilin pathway, destabilizing F-actin. PMID: 28538170
    4. The of loss-of-function and ARHGAP29 missense variants in the etiology of oral clefts PMID: 27350171
    5. Data indicate that through GTPase-activating proteins ArhGAP29 complex formation Rap1 GTP-binding protein spatially restricts Rho-mediated signaling, which is necessary for endothelial barrier potentiation. PMID: 25963656
    6. Genetic variants in ARHGAP29 contribute to the development of nonsyndromic cleft lip with cleft palate. PMID: 25163644
    7. We identified genetic variants in TGFB3 and ARHGAP29 associated with suboptimal healing outcome. PMID: 24635173
    8. Rasip1-ArhGAP29 pathway also functions in Rap1-mediated regulation of endothelial junctions, which controls endothelial barrier function PMID: 23798437
    9. ARHGAP29 is the etiologic gene for the cleft lip with or without cleft palate locus identified by genome-wide association on chromosome 1p22. PMID: 23008150
    10. PARG1 expression was substantially reduced & it displayed at least partial promoter methylation in all investigated mantle-cell lines & in 31 primary cases. PARG1 is a strong candidate tumor suppressor gene in MCL. PMID: 17488656

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  • 组织特异性：
    Widely expressed. Highly expressed in skeletal muscle and heart. Expressed at intermediate level in placenta, liver and pancreas. Weakly expressed in brain, lung and kidney.
  • 数据库链接：

    HGNC: 30207

    OMIM: 610496

    KEGG: hsa:9411

    STRING: 9606.ENSP00000260526

    UniGene: Hs.483238