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ARHGAP11B Antibody

  • 中文名称：
    ARHGAP11B兔多克隆抗体
  • 货号：
    CSB-PA664668LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ARHGAP11B Polyclonal antibody
  • Uniprot No.：
    Q3KRB8
  • 基因名：
    ARHGAP11B
  • 别名：
    ARHGAP11B antibody; FAM7B1 antibody; Rho GTPase-activating protein 11B antibody; Protein FAM7B1 antibody; Rho-type GTPase-activating protein 11B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Rho GTPase-activating protein 11B protein (99-231AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ARHGAP11B Antibody (CSB-PA664668LA01HU)，的标记方式是Non-conjugated。对于ARHGAP11B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA664668LB01HU ARHGAP11B Antibody, HRP conjugated ELISA
    FITC CSB-PA664668LC01HU ARHGAP11B Antibody, FITC conjugated
    Biotin CSB-PA664668LD01HU ARHGAP11B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion. Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP): delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+) concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation. Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development.
  • 基因功能参考文献：
    1. The data also demonstrate that a single C-->G base substitution underlies the ARHGAP11B-mediated basal progenitor amplification implicated in neocortex expansion. PMID: 27957544
    2. ARHGAP11B may have contributed to evolutionary expansion of human neocortex. PMID: 25721503
  • 亚细胞定位：
    Mitochondrion matrix.
  • 数据库链接：

    HGNC: 15782

    OMIM: 616310

    KEGG: hsa:89839

    STRING: 9606.ENSP00000392760

    UniGene: Hs.659621