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  4. Recombinant Human Rho GTPase-activating protein 11B (ARHGAP11B)

Recombinant Human Rho GTPase-activating protein 11B (ARHGAP11B)

  • 中文名称：
    Recombinant Human Rho GTPase-activating protein 11B(ARHGAP11B),Yeast
  • 货号：
    CSB-YP664668HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Rho GTPase-activating protein 11B(ARHGAP11B),Yeast
  • 货号：
    CSB-EP664668HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Rho GTPase-activating protein 11B(ARHGAP11B),Yeast
  • 货号：
    CSB-EP664668HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Rho GTPase-activating protein 11B(ARHGAP11B),Yeast
  • 货号：
    CSB-BP664668HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Rho GTPase-activating protein 11B(ARHGAP11B),Yeast
  • 货号：
    CSB-MP664668HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ARHGAP11B
  • Uniprot No.：
  • 别名：
    ARHGAP11B; FAM7B1; Rho GTPase-activating protein 11B; Protein FAM7B1; Rho-type GTPase-activating protein 11B
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-267
  • 氨基酸序列
    MWDQRLVKLA LLQHLRAFYG IKVKGVRGQC DRRRHETAAT EIGGKIFGVP FNALPHSAVP EYGHIPSFLV DACTSLEEHI HTEGLFRKSG SVIRLKALKN KVDHGEGCLS SAPPCDIAGL LKQFFRELPE PILPADLHEA LLKAQQLGTE EKNKAILLLS CLLADHTVHV LRYFFNFLRN VSLRSSENKM DSSNLAVIFA PNLLQTSEGH EKMSSNAEKK GVYQTLSWKR YQPCWVLMVS VLLHHWKALK KVNMKLLVNI REREDNV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion. Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP): delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+) concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation. Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development.
  • 基因功能参考文献：
    1. The data also demonstrate that a single C-->G base substitution underlies the ARHGAP11B-mediated basal progenitor amplification implicated in neocortex expansion. PMID: 27957544
    2. ARHGAP11B may have contributed to evolutionary expansion of human neocortex. PMID: 25721503
  • 亚细胞定位：
    Mitochondrion matrix.
  • 数据库链接：

    HGNC: 15782

    OMIM: 616310

    KEGG: hsa:89839

    STRING: 9606.ENSP00000392760

    UniGene: Hs.659621