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ARHGAP10 Antibody

  • 中文名称：
    ARHGAP10兔多克隆抗体
  • 货号：
    CSB-PA002012GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    A1A4S6
  • 基因名：
    ARHGAP10
  • 别名：
    Arhgap10 antibody; Graf-related protein 2 antibody; GRAF2 antibody; GTPase regulator associated with focal adhesion kinase 2 antibody; PS GAP antibody; PSGAP antibody; RHG10_HUMAN antibody; Rho GTPase-activating protein 10 antibody; Rho-type GTPase-activating protein 10 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human ARHGAP10
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death.
  • 基因功能参考文献：
    1. ARHGAP10 may serve as a tumor suppressor through inactivating Cdc42, as well as inhibiting cell cycle, replication and BER pathways. PMID: 27010858
    2. In the Australian GWAS, one SNP achieved genomewide significance (p < 5 x 10(-8)) for ND (rs964170 in ARHGAP10 on chromosome 4, p = 4.43 x 10(-8)). PMID: 20158304
    3. PS-GAP is a novel regulator of caspase-activated PAK-2 PMID: 15471851
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cell membrane.
  • 组织特异性：
    High levels of expression in heart and skeletal muscle.
  • 数据库链接：

    HGNC: 26099

    OMIM: 609746

    KEGG: hsa:79658

    STRING: 9606.ENSP00000336923

    UniGene: Hs.368631