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ANXA2R Antibody

  • 中文名称：
    ANXA2R兔多克隆抗体
  • 货号：
    CSB-PA827389
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA827389(ANXA2R Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA827389(ANXA2R Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q3ZCQ2
  • 基因名：
    ANXA2R
  • 别名：
    Annexin 2 receptor antibody; Annexin II receptor antibody; Annexin-2 receptor antibody; ANXA2R antibody; AX2R antibody; AX2R_HUMAN antibody; AXIIR antibody; C5orf39 antibody; Chromosome 5 open reading frame 39 antibody; LOC389289 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human ANXA2R
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.
  • 基因功能参考文献：
    1. Overexpression of AX2R significantly inhibited cell proliferation, migration and tube formation in both types of endothelial cells and increased the expression of KLF2, mediating VEGF and VEGFR2. PMID: 29694949
    2. Data highlighted the crucial role of AXIIR in reducing Mum2C cell viability through inducing apoptosis, while autophagy played a protective role in this process. PMID: 27183438
    3. these subsequent effects might be via suppressing the expression of matrix metalloproteinase 2 and matrix metalloproteinase 9. ... AXIIR participates in angiogenesis, and may be a potential therapeutic target for angiogenesis related diseases PMID: 25633185
    4. AXIIR acts as a novel inducer of apoptosis in human cells, partially through activating Caspase-8. PMID: 23640736
    5. Results show that AXII and AXIIR play important roles in multiple myeloma (MM) and that targeting the AXII/AXIIR axis may be a novel therapeutic approach for MM. PMID: 22223826
    6. analysis of the annexin II receptor on human marrow stromal cells PMID: 16895901
    7. annexin II and its receptor axis play a central role in prostate cancer metastasis, and prostate cancer utilizes the hematopoietic stem cell homing mechanisms to gain access to the niche. PMID: 18636554

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  • 组织特异性：
    Widely expressed. Highly expressed in lymphocytes. Expressed in both resting CD4(+) and CD8(+) T-cells.
  • 数据库链接：

    HGNC: 33463

    OMIM: 611296

    KEGG: hsa:389289

    STRING: 9606.ENSP00000315915

    UniGene: Hs.529385