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ALDH3B1 Antibody

  • 货号：
    CSB-PA945499
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from HuvEc cells, using ALDH3B1 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using ALDH3B1 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ALDH3B1 Polyclonal antibody
  • Uniprot No.：
    P43353
  • 基因名：
    ALDH3B1
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human ALDH3B1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor. May have a protective role against the cytotoxicity induced by lipid peroxidation.
  • 基因功能参考文献：
    1. the likely physiological function of ALDH3B1 is to oxidize lipid-derived aldehydes generated in the plasma membrane and not to be involved in the sphingolipid metabolism in the endoplasmic reticulum. PMID: 23721920
    2. protects cells from the damaging effects of oxidative stress PMID: 20699116
    3. The specificity of ALDH3B1 distribution may prove to be directly related to the functional role of this enzyme in human tissues. PMID: 20729348
    4. This study shows for the first time the functionality, expression and protective role of ALDH3B1 and indicates a potential physiological role of ALDH3B1 against oxidative stress. PMID: 17382292
    5. These findings provided convincing evidence that epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes plays an important role in the pathogenesis of schizophrenia PMID: 19159868
    6. Initial characterization of human ALDH3B1 suggests a potential physiological role of this protein in oxidative stress processes. PMID: 17382292

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.
  • 蛋白家族：
    Aldehyde dehydrogenase family
  • 组织特异性：
    Highest expression in kidney and lung.
  • 数据库链接：

    HGNC: 410

    OMIM: 600466

    KEGG: hsa:221

    UniGene: Hs.523841