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AGGF1 Antibody

  • 货号：
    CSB-PA001444GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8N302
  • 基因名：
    AGGF1
  • 别名：
    AGGF 1 antibody; Aggf1 antibody; AGGF1_HUMAN antibody; Angiogenic factor VG5Q antibody; Angiogenic factor with G patch and FHA domains 1 antibody; G patch domain containing protein 7 antibody; G patch domain-containing protein 7 antibody; GPATC 7 antibody; GPATC7 antibody; GPATCH 7 antibody; GPATCH7 antibody; HSU84971 antibody; HUS84971 antibody; hVG5Q antibody; Vasculogenesis gene on 5q antibody; Vasculogenesis gene on 5q protein antibody; VG5Q antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human AGGF1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.
  • 基因功能参考文献：
    1. Aggf1 has a role in regulating vascular injury. PMID: 28153879
    2. High expression of AGGF1 predicts poor prognosis in gastric cancer patients. PMID: 28289272
    3. AGGF1 gene polymorphism does not affect the risk of varicose veins of the legs in ethnic Russians. PMID: 27704351
    4. Overexpression of AGGF1 is correlated with angiogenesis in hepatocellular carcinoma. PMID: 25796501
    5. AGGF1 reduces myocardial apoptosis and inflammation and enhances angiogenesis, leading to decreased infarct size after I/R injury. PMID: 24893993
    6. results of this study indicate that hypoxia down-regulates expression of the AGGF1 protein, but not AGGF1 mRNA, by inducing expression of miR-27a PMID: 24462738
    7. AGGF1 potently attenuated TNF-alpha triggered NF-kappaB pathway, as indicated by the decreased promoter activity, nuclear distribution and phosphorylation of NF-kappaB p65 subunit as well as the increased protein level of IkappaBalpha. PMID: 23628701
    8. analysis of sphingolipid modulation of angiogenic factor expression in neuroblastoma PMID: 21576349
    9. results define VG5Q as an angiogenic factor, establish VG5Q as a susceptibility gene for Klippel-Trenaunay syndrome, and show that increased angiogenesis is a molecular pathogenic mechanism of KTS PMID: 14961121
    10. VG5Q, E133K is a mutation that causes Klippel-Trenaunay and other overgrowth syndromes. PMID: 16443853
    11. This review describes the somatic mutation for angiogenic factor VG5Q, which may be the cause of the multisystem disorder Klippel-Trenaunay syndrome. PMID: 16911369
    12. identified two tagSNPs, rs13155212 and rs7704267 that capture information for all common variants in AGGF1 as a candidate susceptibility gene for Klippel-Trenaunay syndrome PMID: 18564129
    13. Knockdown of GATA1 expression by siRNA reduced expression of AGGF1, and resulted in endothelial cell apoptosis and inhibition of vessel formation. PMID: 19556247

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  • 相关疾病：
    Klippel-Trenaunay syndrome (KTS)
  • 亚细胞定位：
    Cytoplasm. Secreted. Note=Cytoplasmic in microvascular endothelial cells. Upon angiogenesis, when endothelial cell tube formation is initiated, it is secreted.
  • 组织特异性：
    Widely expressed. Expressed in endothelial cells, vascular smooth muscle cells and osteoblasts. Expressed in umbilical vein endothelial cells and microvascular endothelial cells.
  • 数据库链接：

    HGNC: 24684

    OMIM: 149000

    KEGG: hsa:55109

    STRING: 9606.ENSP00000316109

    UniGene: Hs.634849