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  4. AFAP1 Antibody

AFAP1 Antibody

  • 货号：
    CSB-PA154373
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA154373(AFAP1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA154373(AFAP1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A172 cells, Primary antibody: CSB-PA154373(AFAP1 Antibody) at dilution 1/134, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q8N556
  • 基因名：
    AFAP1
  • 别名：
    110 kDa actin filament associated protein antibody; 110 kDa actin filament-associated protein antibody; Actin filament associated protein 1 antibody; Actin filament associated protein 110 kDa antibody; Actin filament-associated protein 1 antibody; AFAP 1 antibody; AFAP 110 antibody; AFAP antibody; AFAP-110 antibody; Afap1 antibody; AFAP1_HUMAN antibody; AFAP110 antibody; FLJ56849 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human AFAP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Can cross-link actin filaments into both network and bundle structures. May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.
  • 基因功能参考文献：
    1. The observed up-regulation of AFAP1-AS1 in tumor samples compared with ANCTs implies its involvement in breast cancer pathogenesis and potentiates it as a biomarker or therapeutic target. PMID: 29439313
    2. The high LncRNA AFAP1-AS1 expression was significantly related to advanced clinical stage, larger tumor size, earlier tumor metastasis, earlier lymph nodal involvement and vascular invasion. High LncRNA AFAP1-AS1 expression was an unfavorable prognostic factor in various cancers. PMID: 29544748
    3. AFAP-1 is a key mediator in the inflammatory signaling-induced, translocation-independent attenuation of P-glycoprotein efflux in brain capillary endothelial cells. PMID: 28112407
    4. The genotype frequencies of six SNPs in AFAP1, GMDS and PTGFR genes were conformed to Hardy-Weinberg equilibrium (HWE). PMID: 27862086
    5. Data indicate three loci associated with primary open-angle glaucoma (POAG) were located upstream of ATP binding cassette transporter 1 (ABCA1), within actin filament associated protein 1 (AFAP1) and within GDP-mannose 46-dehydratase (GMDS). PMID: 25173105
    6. Methylation of the long noncoding RNA AFAP1-AS1 is reduced in BE and EAC, and its expression inhibits cancer-related biologic functions of EAC cells. PMID: 23333711
    7. AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB 231 breast cancer cells. PMID: 17520695

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, stress fiber.
  • 组织特异性：
    Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF-7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma.
  • 数据库链接：

    HGNC: 24017

    OMIM: 608252

    KEGG: hsa:60312

    STRING: 9606.ENSP00000371983

    UniGene: Hs.529369