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ADPGK Antibody

  • 货号：
    CSB-PA001380ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA001380ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ADPGK Polyclonal antibody
  • Uniprot No.：
    Q9BRR6
  • 基因名：
    ADPGK
  • 别名：
    2610017G09Rik antibody; ADP dependent glucokinase antibody; ADP GK antibody; ADP-dependent glucokinase antibody; ADP-GK antibody; ADPGK antibody; ADPGK_HUMAN antibody; ATP dependent glucokinase antibody; DKFZP434B195 antibody; RbBP 35 antibody; RbBP-35 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human ADP-dependent glucokinase protein (218-497AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency.
  • 基因功能参考文献：
    1. ADPGK is substrate inhibited by high glucose concentration and shows high specificity for glucose, with no activity for other sugars, as determined by NMR spectroscopy, including 2-deoxyglucose PMID: 26555263
    2. ADPGK can contribute to tumour cell survival under conditions of high glycolytic dependence. PMID: 23799003
    3. human ADPGK(ADP-dependent glucokinase) catalyses ADP-dependent phosphorylation of glucose in vitro, but despite its high expression in human tumour cell lines it appears not to make a quantifiable contribution to glycolysis under the conditions evaluated. PMID: 22219026
    4. Glucose and insulin response to oral glucose is higher in GCK(261) carriers, indicating clinical heterogeneity in GCK maturity diabetes carriers. PMID: 19903754
    5. The presence of mild persistent hyperglycemia in any patient without autoantibodies should lead to genetic analysis of glucokinase, particularly if there is a positive family history. PMID: 19309449

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    ADP-dependent glucokinase family
  • 数据库链接：

    HGNC: 25250

    OMIM: 611861

    KEGG: hsa:83440

    STRING: 9606.ENSP00000312250

    UniGene: Hs.562587