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ADAM28 Antibody

  • 货号：
    CSB-PA892455ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: ADAM28 antibody IgG at 5.6μg/ml + PC-3 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 88, 62 kDa
      Observed band size: 88 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA892455ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ADAM28 Polyclonal antibody
  • Uniprot No.：
    Q9UKQ2
  • 基因名：
    ADAM28
  • 别名：
    ADAM28 antibody; ADAM23 antibody; MDCLDisintegrin and metalloproteinase domain-containing protein 28 antibody; ADAM 28 antibody; EC 3.4.24.- antibody; Epididymal metalloproteinase-like antibody; disintegrin-like antibody; and cysteine-rich protein II antibody; eMDC II antibody; Metalloproteinase-like antibody; disintegrin-like antibody; and cysteine-rich protein L antibody; MDC-L antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 28 protein (199-440AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.
  • 基因功能参考文献：
    1. Within placental villi, ADAM28 mRNA levels were highest in HLA-G(+) column trophoblasts, and consistent with this, ADAM28 was preferentially localized to HLA-G(+) trophoblasts within distal anchoring columns and decidual tissue. PMID: 28623976
    2. There is a relationship between the serum level of ADAM28 and the degree of the colonic cancer clinical stage. PMID: 29254295
    3. miR-552 is an oncomir able to promote CRC metastasis in part through a mechanism of targeting ADAM28. PMID: 27661126
    4. The data demonstrate that ADAM28 is expressed by epithelial cells of several normal organs, and suggest that ADAM28 plays a role in cell survival by suppression of C1q-induced cytotoxicity in bronchial epithelial cells. PMID: 26918856
    5. ADAM28 is overexpressed in primary human prostate tumor biopsies, and it promotes human prostate cancer cell proliferation and migration. PMID: 27749584
    6. The results of this study suggest that these proteins play important roles in pulmonary inflammatory reactions elicited against etiological viral agents. PMID: 25453333
    7. Src is an inducer of ADAM28 gene expression through the MEK/extracellular signal-regulated kinase and PI3K/mammalian target of rapamycin pathways. PMID: 24007880
    8. IL-1beta-induced MMP-13 expression and changes in cell proliferation and apoptosis in alpha7(+)hSMSC-OB cells are regulated by ADAM-28. PMID: 24613731
    9. Sequence analysis of ADAM28 genes did not reveal any putative mutations for hyperostosis cranialis interna to chromosome 8p21 PMID: 23640157
    10. The change of ADAM28 and IGFBP-3 gene expression is present in the normal tissue in overweight/obese patients with colorectal cancer only, and the observed variability of ADAM28 and IGFBP-3 expression may be an initial process of cancer proliferation PMID: 23527725
    11. High ADAM28 expression is associated with B-Cell Chronic Lymphocytic Leukemia. PMID: 23643150
    12. Human ADAM28 expression levels were positively correlated with parameters of the metabolic syndrome. PMID: 23010875
    13. ADAM28 cleaves and inactivates proapoptotic VWF in carcinoma cells and enhances lung metastasis probably by promoting carcinoma cell survival within the blood vessels. PMID: 22636800
    14. Study shows using proteomics that ADAM28 may be used as a possible biomarker of bladder cancer. PMID: 21913264
    15. ADAM28 showed significant differences compared with normal individuals, so it may be a biomarker of bladder cancer. PMID: 21782798
    16. ADAM28 might actively participate in manipulating the proliferation, differentiation, and apoptosis of human dental pulp stem cells (HDPSCs). PMID: 21329817
    17. It plays a role in cancer cell proliferation, invasion and metastasis. (review) PMID: 21077327
    18. These data provide the first evidence that CTGF is a novel substrate of ADAM28 and suggest that ADAM28 may promote VEGF(165)-induced angiogenesis in the breast carcinomas by the CTGF digestion in the CTGF/VEGF(165) complex. PMID: 20971063
    19. High ADAM28 in serum is associated with non-small-cell lung cancers. PMID: 20112342
    20. Upregulation of ADAM28 is associated with asbestos-related lung adenocarcinomas. PMID: 20544843
    21. was able to effectively manipulate the proliferation, apoptosis, and differentiation of human periodontal ligament stem cells PMID: 20450360
    22. overexpression of A disintegrin and metalloproteinase 28 was increased according to its histologic grade in conventional chondrosarcoma and could be one of the helpful tools in distinguishing between low-grade chondrosarcoma and enchondroma. PMID: 19896699
    23. ADAM8, ADAM15, and ADAM28, but not ADAM17, catalyzed ectodomain shedding of CD23, the low affinity IgE receptor. PMID: 12777399
    24. data demonstrate for the first time that ADAM28 is overexpressed and activated in human non-small cell lung carcinomas, and suggest the possibility that ADAM28 plays a role in cell proliferation and progression of the human lung carcinomas PMID: 16052521
    25. ADAM28 is overexpressed in an activated form in breast carcinoma cells and suggest ADAM28 is involved in cell proliferation through enhanced bioavailability of IGF-I released from the IGF-I/IGFBP-3 complex by IGFBP-3 cleavage in breast carcinomas. PMID: 17047053
    26. ADAM28s promotes PSGL-1/P-selectin-mediated leukocyte rolling adhesion to endothelial cells and subsequent infiltration into tissue spaces through interaction with PSGL-1 PMID: 17597069
    27. Report essential role of ADAM28 in regulating the proliferation and differentiation of human dental papilla mesenchymal cells. PMID: 18690470
    28. These results indicate that ADAM28 participates in proteoglycan degradation. PMID: 19527685

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  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
  • 组织特异性：
    Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed pref
  • 数据库链接：

    HGNC: 206

    OMIM: 606188

    KEGG: hsa:10863

    STRING: 9606.ENSP00000265769

    UniGene: Hs.174030