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ACTRT1 Antibody

  • 货号：
    CSB-PA001255LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA001255LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA001255LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA001255LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human smooth muscle tissue using CSB-PA001255LA01HU at dilution of 1:100
    • Immunofluorescence staining of PC-3 cells with CSB-PA001255LA01HU at 1:100,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ACTRT1 Polyclonal antibody
  • Uniprot No.：
    Q8TDG2
  • 基因名：
    ACTRT1
  • 别名：
    ACTRT1 antibody; ARPT1 antibody; HSD27Actin-related protein T1 antibody; ARP-T1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Actin-related protein T1 protein (201-376AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ACTRT1 Antibody (CSB-PA001255LA01HU)，的标记方式是Non-conjugated。对于ACTRT1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA001255LB01HU ACTRT1 Antibody, HRP conjugated ELISA
    FITC CSB-PA001255LC01HU ACTRT1 Antibody, FITC conjugated
    Biotin CSB-PA001255LD01HU ACTRT1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression.
  • 基因功能参考文献：
    1. Study identified mutations in the ACTRT1 gene, which encodes actin-related protein T1 (ARP-T1), in two of the six families with Bazex-Dupre-Christol syndrome (BDCS) that were examined in this study. ARP-T1 was found to directly bind to the GLI1 promoter, thus inhibiting GLI1 expression, and loss of ARP-T1 led to activation of the Hedgehog pathway in individuals with BDCS. PMID: 28869610
    2. Describes the discovery of two actin-related proteins as major components in a cytoskeletal, nonmotile structure of bull spermatozoa, suggesting that certain members of this family of proteins may serve functions other than nucleation of actin filaments. PMID: 12243744
  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm. Nucleus.
  • 蛋白家族：
    Actin family
  • 组织特异性：
    In skin, expressed in the basal, spinous and granular layers of the epidermis. Also expressed in hair follicles, sebaceaous glands, eccrine sweat glands and semen.
  • 数据库链接：

    HGNC: 24027

    OMIM: 300487

    KEGG: hsa:139741

    STRING: 9606.ENSP00000360165

    UniGene: Hs.680125