Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. ACOT7 Antibody

ACOT7 Antibody

  • 货号：
    CSB-PA001169ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA001169ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ACOT7 Polyclonal antibody
  • Uniprot No.：
    O00154
  • 基因名：
    ACOT7
  • 别名：
    ACH1 antibody; ACOT 7 antibody; ACOT7 antibody; ACT antibody; Acyl CoA thioesterase 7 antibody; Acyl CoA thioesterase long chain antibody; Acyl-CoA thioesterase 7 antibody; BACH antibody; BACH_HUMAN antibody; Brain acyl CoA hydrolase antibody; Brain acyl-CoA hydrolase antibody; CTE-II antibody; CTE-IIa antibody; Cytosolic acyl coenzyme A thioester hydrolase antibody; hBACH antibody; LACH antibody; LACH1 antibody; Long chain acyl-CoA thioester hydrolase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cytosolic acyl coenzyme A thioester hydrolase protein (151-380AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18. May play an important physiological function in brain.
  • 基因功能参考文献：
    1. PKCzeta was specifically involved in ACOT7 depletion-mediated cell cycle arrest as an upstream molecule of the p53-p21 signaling pathway in MCF7 human breast carcinoma and A549 human lung carcinoma cells. PMID: 28518146
    2. WIG1 governs the miRNA-dependent and the miRNA-independent recruitment of AGO2 to lower the stability of and suppress the translation of ACOT7 mRNA. PMID: 28472401
    3. the human BACH gene can express long-chain acyl-CoA hydrolase activity in multiple intracellular compartments by generating BACH isoforms with differential localization signals to affect various cellular functions that involve acyl-CoAs PMID: 12435388
    4. BACH was deranged in hippocampus of mesial temporal lobe epilepsy patients. PMID: 15592755
  • 亚细胞定位：
    [Isoform 4]: Cytoplasm, cytosol.; [Isoform 6]: Cytoplasm, cytosol.; [Isoform 1]: Mitochondrion.; [Isoform 5]: Mitochondrion.
  • 组织特异性：
    Isoform 4 is expressed exclusively in brain.
  • 数据库链接：

    HGNC: 24157

    OMIM: 602587

    KEGG: hsa:11332

    STRING: 9606.ENSP00000367086

    UniGene: Hs.126137