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  4. ABL2 Antibody

ABL2 Antibody

  • 货号：
    CSB-PA119696
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA119696(ABL2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA119696(ABL2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, Jurkat cells, Primary antibody: CSB-PA119696(ABL2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

产品详情

  • Uniprot No.：
    P42684
  • 基因名：
  • 别名：
    Abelson murine leukemia viral oncogene homolog 2 antibody; Abelson related gene protein antibody; Abelson tyrosine-protein kinase 2 antibody; Abelson-related gene protein antibody; ABL2 antibody; ABL2_HUMAN antibody; ABLL antibody; ARG antibody; Tyrosine kinase ARG antibody; Tyrosine protein kinase ABL2 antibody; Tyrosine-protein kinase ARG antibody; v abl Abelson murine leukemia viral oncogene homolog 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human ABL2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
  • 基因功能参考文献：
    1. These data evidence a new specific involvement of Arg kinase into the regulation of TGF-beta1 expression in tubular cells under high-glucose conditions. PMID: 27298228
    2. Q112H mutation hinders the ability of the protein to interact with Abl kinase, leading to defective tyrosine phosphorylation and a resultant defect in respiration PMID: 27913209
    3. the ETV6/ARG oncoprotein contributes to autonomous cell growth by compensating for the requirement of growth factor through activating STAT5 signaling, which leads to the up-regulation of c-Myc. PMID: 25373509
    4. Two distinct interfaces mediate direct binding of integrin beta1 with Arg in vitro and in cells and promote Arg kinase activation. PMID: 25694433
    5. Knockdown of ABL2 promoted cell invasion and migration and we identified miR-20a-induced cell invasion and migration can be rescued by ABL2. PMID: 24464651
    6. Data shows that c-Abl and Arg induce NM23-H1 degradation by increasing expression and activation of cathepsin L and B, which directly cleave NM23-H1 in the lysosome. PMID: 24096484
    7. data provide evidence that Aurora A, AMPK, ABL and CDKs are functionally integrated into human cytomegalovirus (HCMV) replication; inhibition of AMPK and ABL kinases exerted a negative effect, inhibition of Aurora A kinase a slightly positive effect on HCMV replication PMID: 23648710
    8. Beta1 integrin regulates Arg to promote invadopodial maturation and matrix degradation. PMID: 23552693
    9. ARG isoforms's cellular location modulate cell morphology, motility, the cytoskeleton, and focal adhesions. PMID: 23707396
    10. Arg acts as a switch in metastatic cancer cells that governs the decision to 'grow or go' (divide or invade). PMID: 22777352
    11. Knockout mutation of p27-p55 operon in Mycobacterium bovis severely decreased the virulence of the bacteria when assessed in a progressive model of pulmonary tuberculosis in Balb/c mice. PMID: 21543883
    12. Our findings suggest a novel mechanism by which an EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion PMID: 21257711
    13. The Arg tyrosine kinase regulated lysosomal degradation of antiapoptotic Gal3 may provide one of the important arms in Arg tyrosine kinase dependent antiapoptotic pathways. PMID: 20150913
    14. A 35-bp insertion in the BCR-ABL2 gene is associated with resistance to tyrosine kinase inhibitors, but sensitivity to omacetaxine in chronic myelogenous leukemia. PMID: 20448119
    15. Results describe the NMR structure of human Arg F-actin-binding domain. PMID: 20077570
    16. The highest Arg transcript and protein levels are in the mature B cells. PMID: 12220663
    17. High Arg expression is correlated with thymoma stage PMID: 15679048
    18. several critical domains within TEL/ARG necessary for function PMID: 15729383
    19. ABL2/ARG is a novel mediator of SEMA3F-induced RhoA inactivation and collapsing activity. PMID: 18660502

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, ABL subfamily
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 77

    OMIM: 164690

    KEGG: hsa:27

    STRING: 9606.ENSP00000427562

    UniGene: Hs.159472