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AASS Antibody

  • 货号：
    CSB-PA000779
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HeLa cells using AASS Polyclonal Antibody
    • Western Blot analysis of 293 NIH-3T3 A549 cells using AASS Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9UDR5
  • 基因名：
  • 别名：
    AASSAlpha-aminoadipic semialdehyde synthase antibody; mitochondrial antibody; LKR/SDH) [Includes: Lysine ketoglutarate reductase antibody; LKR antibody; LOR antibody; EC 1.5.1.8); Saccharopine dehydrogenase antibody; SDH antibody; EC 1.5.1.9)] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human AASS.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively.
  • 基因功能参考文献：
    1. GR and KLF15 physically interact via low affinity GR binding sites within glucocorticoid response elements (GREs) for PRODH and AASS that contribute to combinatorial regulation with KLF15. PMID: 26088140
    2. Mitochondrial NADPH is crucial for AASS function PMID: 24847004
    3. Hyperlysinemia is caused by mutations in AASS PMID: 23570448
    4. Isolation and characterization of the mouse ortholog. PMID: 10567240
  • 相关疾病：
    Hyperlysinemia, 1 (HYPLYS1); 2,4-dienoyl-CoA reductase deficiency (DECRD)
  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    AlaDH/PNT family; Saccharopine dehydrogenase family
  • 组织特异性：
    Expressed in all 16 tissues examined with highest expression in the liver.
  • 数据库链接：

    HGNC: 17366

    OMIM: 238700

    KEGG: hsa:10157

    STRING: 9606.ENSP00000377040

    UniGene: Hs.156738