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  4. Recombinant Mouse Pro-interleukin-16 [Cleaved into: Interleukin-16 protein (Il16)

Recombinant Mouse Pro-interleukin-16 [Cleaved into: Interleukin-16 protein (Il16)

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  • 中文名称：
    小鼠Il16重组蛋白
  • 货号：
    CSB-AP003381MO
  • 规格：
    ￥2124
  • 图片：
  • 其他：

产品详情

  • 纯度：
    >98% as determined by SDS-PAGE.
  • 内毒素：
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性：
    Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral T lymphocytes is in a concentration range of 1.0-100 ng/ml.
  • 基因名：
    Il16
  • Uniprot No.：
  • 别名：
    Il16; Pro-interleukin-16 [Cleaved into: Interleukin-16; IL-16; Lymphocyte chemoattractant factor; LCF)]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.Coli
  • 分子量：
    12.2 kDa
  • 表达区域：
    1205-1322aa
  • 氨基酸序列
    SAASASAASD ISVESKEATV CTVTLEKTSA GLGFSLEGGK GSLHGDKPLT INRIFKGTEQ GEMVQPGDEI LQLAGTAVQG LTRFEAWNVI KALPDGPVTI VIRRTSLQCK QTTASADS
  • 蛋白标签：
    Tag-Free
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    0.2 μm filtered PBS, pH 7.4 ,lyophilized
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    5-10 business days
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.; Isoform 2 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
  • 基因功能参考文献：
    1. The production of IL-16 contributed to lung damage as neutralization of IL-16 enhanced S. aureus clearance and resulted in diminished lung pathology in S. aureus pneumonia. PMID: 24736233
    2. Data indicate that knockdown of translocator protein TSPO by siRNAhad showed no effect on the productions of TNF-alpha, IL-1beta and IL-6 in lipopolysaccharide (LPS)-stimulated BV-2 microglia cells. PMID: 25200148
    3. Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction. PMID: 23894370
    4. Data show overexpression of pro-IL-16 impaired resting B cell proliferation mediated through regulating nuclear factor (NF)-kappaB activation, and siRNA knock-down of pro-IL-16 expression decreased the level of p27(kip) and increased the level of Skp2. PMID: 23297678
    5. We determined that ovalbumin (OVA)-sensitized mice have an increase in systemic tumor necrosis factor-alpha levels, and that serum or BAL fluid stimulation of bronchial epithelial cells results in production of IL-16 PMID: 12594062
    6. IL-16 induces a greater migratory response in the Th1 cell subset than in the Th2 subset. PMID: 14607889
    7. interleukin-16 and its precursor have roles in T lymphocyte activation and growth [review] PMID: 15253385
    8. IL-16 precursor mRNA and protein expression are dynamically regulated during CD4+ T cell activation by a calcineurin-dependent mechanism; pro-IL-16 may influence T cell cycle regulation, although not in a dominant manner. PMID: 15728482
    9. Caspase-3 mediated production of IL-16 by infiltrating CD4+ T cells, contributes to ongoing neuroinflammation by chemoattraction of additional waves of CD4+ T cells. PMID: 16271292
    10. After femoral artery ligation, CD8+ T cells infiltrate the site of collateral vessel growth and recruit CD4+ mononuclear cells through the expression of IL-16 PMID: 16380545
    11. Inactivation of IL-16 by antibody therapy or IL-16 deficiency prevented ischemia-reperfusion injury of the kidney, as shown by reduced levels of serum creatinine or blood urea nitrogen. PMID: 18004294
    12. Generation of bleomycin-induced lung fibrosis is independent of IL-16 PMID: 19232499
    13. CD4-positive T cells are specifically recruited to the lung in a dendritic cell-independent but IL-16-dependent process and diminish neutrophil recruitment through increased IL-10 production. PMID: 19641139

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  • 亚细胞定位：
    Secreted.; [Isoform 1]: Cytoplasm. Note=Colocalizes with GRIN2C in neuronal cell bodies and neurites.; [Isoform 2]: Cytoplasm. Nucleus.
  • 组织特异性：
    Isoform 1 is expressed in neurons of the cerebellum and hippocampus. Isoform 2 is expressed in thymus, spleen and lung.
  • 数据库链接：

    KEGG: mmu:16170

    STRING: 10090.ENSMUSP00000001792

    UniGene: Mm.10137