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  4. Rat VGF Nerve Growth Factor Inducible (VGF) ELISA Kit

Rat VGF Nerve Growth Factor Inducible (VGF) ELISA Kit

  • 中文名称：
    大鼠VGF神经生长因子诱导蛋白(VGF)酶联免疫试剂盒
  • 货号：
    CSB-E17520r
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    The Rat VGF Nerve Growth Factor Inducible (VGF) ELISA Kit is a powerful tool for researchers in the field of neuroscience. This quantitative assay measures the concentration of VGF Nerve Growth Factor Inducible (VGF) in serum and plasma samples from Rattus norvegicus (Rat).

    With a detection range of 0.312 ng/mL to 20 ng/mL and a sensitivity of 0.078 ng/mL, this ELISA kit provides accurate and precise measurements for your research needs. The assay time ranges from 1 to 5 hours, and the sample volume required is 50-100ul.

    The sandwich measurement technique used in this kit ensures high specificity and sensitivity, providing you with reliable and consistent results. The detection wavelength of 450 nm ensures accurate measurements for each sample.

    This ELISA kit is particularly useful for researchers in the field of neuroscience, as VGF has been linked to neuronal development and plasticity, as well as cognitive function and behavior. This kit can help investigate the role of VGF in these processes and provide insights into potential therapeutic targets.

  • 别名：
    VgfNeurosecretory protein VGF ELISA kit; VGF8a protein) [Cleaved into: VGF(24-63); VGF(180-194); VGF(375-407); Neuroendocrine regulatory peptide-1 ELISA kit; NERP-1); Neuroendocrine regulatory peptide-2 ELISA kit; NERP-2); VGF-derived peptide TLQP-11; VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-30; VGF-derived peptide TLQP-62; VGF-derived peptide HFHH-10; VGF-derived peptide AQEE-30; VGF-derived peptide LQEQ-19] ELISA kit
  • 缩写：
    VGF
  • Uniprot No.：
  • 种属：
    Rattus norvegicus (Rat)
  • 样本类型：
    serum, plasma
  • 检测范围：
    0.312 ng/mL-20 ng/mL
  • 灵敏度：
    0.078 ng/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Neuroscience
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner. VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain.; Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons.; Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons. Stimulates also feeding behavior in an orexin-dependent manner in the hypothalamus. Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying.; Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis. Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes. Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity.; Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation. Induces also insulin secretion in insulinoma cells by increasing intracellular calcium mobilization.
  • 基因功能参考文献：
    1. Results indicate that neuron-restrictive silencer factor plays an important role as a repressor of VGF gene regulation in neuroblastoma cells through a mechanism that is dependent on VGF-neuron-restrictive silencer element PMID: 25569790
    2. various VGF peptides may regulate the hypothalamus-pituitary complex via specific neuroendocrine mechanisms while TLQP peptides may act at further, multiple levels via endocrine mechanisms involving the ovary. PMID: 25280008
    3. VGF is involved in the control of metabolism and body weight homeostasis; active peptide fragments are generated from VGF, including TLQP-21, which controls reproductive function in female rats. PMID: 23485923
    4. These results indicate that gC1qR is the receptor for TLQP-21 and plays an important role in chronic pain through activation of macrophages PMID: 24106277
    5. VGF expression under continuous stress is negatively regulated by dopaminergic neurons projecting from the hypothalamus. PMID: 23541636
    6. Specific VGF peptides appear to be widely represented in different gastric endocrine and other mucosal cell populations. PMID: 20876237
    7. VGF protein is primarily cleaved at 10 sites through the processing pathway common to the brain and gastrointestinal tract. PMID: 20524965
    8. Analysis of the contractile activity of VGF-derived peptides, biologically active in other systems, shows that only TLQP-21, corresponding to the 556-576 amino acid fragment of VGF precursor protein, can influence gastrointestinal contraction in vitro. PMID: 19466987
    9. VGF neuropeptides may regulate synaptic function in hippocampal neurons; C-terminal VGF peptides acutely increased synaptic charge in a dose-dependent manner PMID: 14645472
    10. molecular mechanisms of its sorting to the regulated and polarized pathways of secretion PMID: 15051509
    11. The identification in the Central nervous system of a previously uncharacterized VGF-derived peptide and its chronic i.c.v. infusion effected an increase in energy expenditure and limited the early phase of diet-induced obesity, is reported. PMID: 16983076
    12. the exercise-regulated gene VGF has an antidepressant effect PMID: 18059283
    13. Prolonged upregulation of VGF mRNA and protein was observed in injured dorsal root ganglion neurons, central terminals and their target dorsal horn neurons PMID: 19077191

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  • 亚细胞定位：
    [Neurosecretory protein VGF]: Secreted. Cytoplasmic vesicle, secretory vesicle.
  • 组织特异性：
    Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells. VGF and several of the derived peptides are present in the brain.
  • 数据库链接：

    KEGG: rno:29461

    STRING: 10116.ENSRNOP00000050024

    UniGene: Rn.9704