Rat Nuclear factor-kappa B(NF-κB) ELISA Kit
-
中文名称:大鼠核因子κB(NF-κB)酶联免疫试剂盒
-
货号:CSB-E13148r
-
规格:96T/48T
-
价格:¥3800/¥2500
-
其他:
产品详情
-
产品描述:NFKB1(核因子κB亚单位1,Nuclear Factor Kappa B Subunit 1)是核因子κB(NF-κB)的亚单位之一,是一种转录因子,参与调控免疫和炎症反应。NFKB1的激活可以诱导多种免疫和炎症相关基因的表达,包括细胞因子、炎症介质等,从而促进炎症反应。NFKB1的异常表达与多种疾病的发生和发展相关。j9九游会登录入口首页生物所提供的Rat Nuclear factor-kappa B(NF-κB) ELISA Kit属于ELISA检测试剂盒,采用双抗夹心法定量检测大鼠血清、血浆、组织匀浆样本中的NFKB1,其灵敏度为0.39 pg/mL,检测范围为1.56 pg/mL-100 pg/mL。
-
别名:Nfkb1 ELISA Kit; Nuclear factor NF-kappa-B p105 subunit ELISA Kit; DNA-binding factor KBF1 ELISA Kit; EBP-1 ELISA Kit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] ELISA Kit; Fragment ELISA Kit
-
缩写:
-
Uniprot No.:
-
种属:Rattus norvegicus (Rat)
-
样本类型:
-
检测范围:
-
灵敏度:
-
反应时间:1-5h
-
样本体积:50-100ul
-
检测波长:450 nm
-
研究领域:Cell Biology
-
测定原理:quantitative
-
测定方法:Sandwich
-
精密度:
-
线性度:
-
回收率:
-
标准曲线:
-
数据处理:
-
货期:3-5 working days
引用文献
- An Analysis of the Intestinal Microbiome Combined with Metabolomics to Explore the Mechanism of How Jasmine Tea Improves Depression in CUMS-Treated Rats Y Zhang, Y Lin, Y Xiong, J Huang, Z Liu,Foods,2024
- Implementing losartan potassium-laden pegylated nanocubic vesicles as a novel nanoplatform to alleviate cisplatin-induced nephrotoxicity via blocking apoptosis and activating the wnt/β-catenin/TCF-4 pathway HF Salem, MM Nafady, RA Khallaf, AR Abdel-Sattar,Life Sciences,2024
- Zeolite abrogates cadmium-induced testicular damage in rats: implication of NF-κB/TNF-α/IL-1β Pathway NM Ibrahim,Arquivo Brasileiro de Medicina Veterinária e Zootecnia,2024
- Rhoifolin protects cisplatin mediated pulmonary toxicity via attenuation of oxidative stress, inflammatory response, apoptosis and histopathological damages A Akbar,JOURNAL OF KING SAUD UNIVERSITY SCIENCE,2024
- Impacts of Echinacea purpurea on the immune-reproductive changes associated with the aging process in male rats KH Mohamed,African Journal of Biological Sciences,/
- Markers of oxidative stress and inflammation increase in the lung and liver of partially irradiated rats AB Abdelrazzak,/,2024
- Rice bran extract mitigates depressive-like behavior in dextran sulfate sodium-induced colitis: Involvement of the gut-brain axis and Sirt1 signaling pathway HM Shendy,Food and chemical toxicology,2023
- Evaluation of Possible Ameliorative Role of Robinetin to Counteract Polystyrene Microplastics Instigated Renal Toxicity in Rats MU Ijaz,/,2024
- Apigetrin ameliorates doxorubicin prompted testicular damage: biochemical, spermatological and histological based study MU Ijaz,Scientific reports,2024
- Schisandrin B ameliorates adjuvant-induced arthritis in rats via modulation of inflammatory mediators, oxidative stress, and HIF-1α/VEGF pathway X Chen,The Journal of pharmacy and pharmacology,2024
相关产品
问答及客户评论
How can I convert pyggrams per decilitre to picograms per milligram, because your kits are in deciliters and concentrates
picogeram/dl---picogeram/mg
this kits according to picogerm/dl, i want according to picogeram /mg
Pls let me know if you have any further questions. Thank you.
靶点详情
-
最新研究进展:NFKB1是一种转录因子,能够介导炎症、免疫反应、细胞生长和凋亡等多种生物学过程。最新的研究发现,NFKB1在人类疾病的发生和发展中发挥着重要作用。例如,研究人员发现NFKB1在肿瘤的发生和转移中发挥了重要作用,并且抑制NFKB1的活性可以抑制肿瘤的生长。此外,NFKB1也参与了许多自身免疫性疾病的发生和发展,如类风湿性关节炎和炎症性肠病等。
-
功能:NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. Plays a role in the regulation of apoptosis. Isoform 5, isoform 6 and isoform 7 act as inhibitors of transactivation of p50 NF-kappa-B subunit, probably by sequestering it in the cytoplasm. Isoform 3 (p98) (but not p84 or p105) acts as a transactivator of NF-kappa-B-regulated gene expression. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.
-
亚细胞定位:Nucleus. Cytoplasm.
-
数据库链接:
STRING: 10116.ENSRNOP00000028944
UniGene: Rn.2411