Rat Interleukin 10,IL-10 ELISA KIT
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中文名称:大鼠白介素10(IL-10)酶联免疫试剂盒
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货号:CSB-E04595r
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规格:96T/48T
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价格:¥3600/¥2500
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其他:
产品详情
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产品描述:IL-10是一种抗炎细胞因子,由多种细胞产生,如单核细胞、B细胞和T细胞。IL-10的作用包括抑制炎症反应、降低细胞因子和白细胞的活性。它还参与调节细胞生长和增殖。j9九游会登录入口首页生物所提供的Rat Interleukin 10,IL-10 ELISA KIT属于ELISA检测试剂盒,采用双抗夹心法定量检测大鼠血清、血浆、细胞培养上清、组织匀浆样本中的IL10,其灵敏度为0.78 pg/mL,检测范围为3.12 pg/mL-200 pg/mL。
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别名:Il10 ELISA Kit; Il-10Interleukin-10 ELISA Kit; IL-10 ELISA Kit; Cytokine synthesis inhibitory factor ELISA Kit; CSIF ELISA Kit
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缩写:
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Uniprot No.:
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种属:Rattus norvegicus (Rat)
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样本类型:serum, plasma, cell culture supernates, tissue homogenates.
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检测范围:3.12 pg/ml-200 pg/ml.
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灵敏度:0.78 pg/ml.
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反应时间:1-5h
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样本体积:50-100ul
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检测波长:450 nm
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研究领域:Immunology
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测定原理:quantitative
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测定方法:Sandwich
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数据处理:
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货期:3-5 working days
引用文献
- Acute Toxicity and Hepatoprotective Influence of Hypericum perforatum Against Thioactamid-Induced Liver Fibrosis in Rats AAJ Jabbar,/,2024
- Mesenchymal stem cell-derived exosomes promote tissue repair injury in rats with liver trauma by regulating gut microbiota and metabolism B Yi,Molecular and cellular probes,2024
- Three Birds, One Stone: An Osteo-Microenvironment Stage-Regulative Scaffold for Bone Defect Repair through Modulating Early Osteo-Immunomodulation, Middle Neovascularization, and Later Osteogenesis Y Yuan,Advanced science,2023
- Eobania vermiculata whole-body muscle extract-loaded chitosan nanoparticles enhanced skin regeneration and decreased pro-inflammatory cytokines in vivo A Farid,Journal of nanobiotechnology,2023
- Investigating the therapeutic potential of sinomenine in rheumatoid arthritis: anti-inflammatory, antioxidant, and immunomodulatory mechanisms J Li,Naunyn-Schmiedeberg's archives of pharmacology,2023
- Sertraline Pre-Treatment Attenuates Hemorrhagic Transformation Induced in Rats after Cerebral Ischemia Reperfusion via Down Regulation of Neuronal CD163: Involvement of M1/M2 Polarization Interchange and Inhibiting Autophagy SK Mohamed,Journal of neuroimmune pharmacology,2023
- Hepatoprotective effects of Gynura procumbens against thioacetamide-induced cirrhosis in rats: Targeting inflammatory and oxidative stress signalling pathways AA Jabbar,Heliyon,2023
- Chitosan-Low Molecular Weight Heparin Sodium Nanoparticles Regulate Treg/Th17 Immune Balance and Inflammation at the Maternal-Fetal Interface to Ameliorate Pre-Eclampsia by HB-EGF M Peng,Advanced Therapeutics,2023
- Intravenous infusion of small umbilical cord mesenchymal stem cells could enhance safety and delay retinal degeneration in RCS rats Q Liang,BMC ophthalmology,2023
- Therapeutic Potential of Curcumin in a Rat Model of Dextran Sulfate Sodium–Induced Ulcerative Colitis by Regulating the Balance of Treg/Th17 Cells J Guo,Inflammation,2023
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问答及客户评论
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靶点详情
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最新研究进展:IL-10是一种免疫调节因子,能够抑制炎症反应和免疫细胞的激活。最近的研究表明,IL-10参与多种疾病的发生和发展,如炎症性肠病、自身免疫性疾病、感染性疾病等。此外,IL-10在某些疾病中也有治疗作用,如克罗恩病、银屑病等。
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功能:Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling.
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基因功能参考文献:
- Low IL10 expression is associated with liver fibrosis. PMID: 30243650
- A modified pectic polysaccharide from turmeric (Curcuma longa) with antiulcer effects via anti-secretary, mucoprotective and IL-10 mediated anti-inflammatory mechanisms. PMID: 29924982
- IL10 suppressed inflammation, facilitated retinal pigment epithelium cell apoptosis and inhibited cell proliferation and migration through the regulation of VEGF expression in rhegmatogenous retinal detachment. PMID: 29568872
- ghrelin with high doses (80 and 160 mug/kg) significantly reduced pain intensity in both the early and the late phases of pain. The serum levels of cytokines, IL-10, and TGF-beta1 showed a significant elevation with ghrelin at the dose of 160 mug/kg. PMID: 27703278
- IL-10 not only attenuates neuronal apoptosis, but also promotes neurite outgrowth and synapse formation via the JAK1/STAT3 signaling pathway. PMID: 27456198
- both the AV and the LV vector systems were able to transfect limbal graft tissue ex vivo with biologically active IL-10, leading to delayed rejection compared to the controls. PMID: 28925732
- Addition of 320 (48) and 640 (96) mg/L (mg/kg BW) boron markedly reduced the serum IgG concentrations; splenic IL-2 and IL-10 expression; the number of CD3(+), CD4(+) and PCNA(+) cells; and increased the number of splenic CD8(+) and caspase-3(+) cells and promoted caspase-3 expression in CD3(+) cells. PMID: 28092075
- The expression levels of IL-10, NF-kappaB and MMP-3 in the intervertebral disc tissue samples were higher in test animals than in controls at one-month, three-months and six-months after surgically induced cervical spondylosis. Cervical degeneration may be accompanied by changes in IL-10. PMID: 29197741
- Comparative Modulation of Levels of Oxidative Stress in the Liver of Anti-Tuberculosis Drug Treated Wistar Rats by Vitamin B12, Beta-Carotene, and Spirulina fusiformis: Role of NF-kappaB, iNOS, IL-6, and IL-10.( PMID: 28387444
- the effects of dapagliflozin on STAT3 activity and myocardial IL-10 levels can be reversed by 3-morpholinosydnonimine, a peroxynitrite generator. Taken together, these observations provide a novel mechanism of SGLT2 inhibitors-mediated M2 polarization through a RONS-dependent STAT3-mediated pathway and selective SGLT2 inhibitors are more effective in attenuating myofibroblast infiltration during postinfarction remodeling PMID: 28132924
- TNF-alpha, IL-6 and IL-10 expressions, responsible for disparity in action of curcumin against cisplatin-induced nephrotoxicity in rats. PMID: 28258441
- this study shows that transduction of interleukin-10 through renal artery attenuates vascular neointimal proliferation and infiltration of immune cells in rat renal allograft PMID: 27317647
- this study shows that that N-Acetyl-l-cysteine acts as an antipyretic via IL-10 stimulation PMID: 27363620
- Transplantation of mesenchymal stem cells overexpressing IL10 preserves myocardial viability and left ventricular rfunction in rats with myocardial infarction. PMID: 28322445
- The bactericidal activity of caspase-6-/- macrophages was impaired compared to wild type cells. Caspase-6-/- mice showed higher expression of the IL-1b gene, known to be detrimental in murine melioidosis. Expression of the IL-10 gene was also increased in caspase-6-/- mice as early as 6 hours after infection. Treatment with exogenous IL-10 rendered mice more susceptible against B. pseudomallei challenge PMID: 28686630
- use of rebamipide retards CCl4-induced hepatic fibrosis, which is associated with significant increases in liver levels of IL-10 PMID: 26849241
- Data suggest that vitamin A, when used as an unnecessary dietary supplement, decreases skeletal muscle expression of anti-inflammatory mediators interleukin-10 and heat shock protein 70, important factors for positive exercise adaptations and tissue damage prevention. PMID: 28368329
- Exercise combined with ultrasound attenuates neuropathic pain in rats and is associated with downregulation of IL-6 and TNF-alpha, and with upregulation of IL-10. PMID: 28319508
- Results uncover a novel neuroimmune modulation of GABAergic neurotransmission as well as a novel role for IL-10 in response to acute ethanol intake. Early increase in IL-10 levels may contribute to the complex changes in neuroimmune signaling that occur after acute exposure to ethanol. Further, IL-10 has an inhibitory effect on GABAergic transmission, possibly leading to inhibition of sleep PMID: 27016017
- Nonsteroidal Anti-Inflammatory Drugs data provide opportunities to investigate such associations and specifically imply that potential interrelationships among OTC NSAID use, IL-10 genotype, and IL-10 cytokine levels deserve further study PMID: 28135825
- The expression of IL-10 and TGF-beta in the CD25 siRNA group increased, while IFN-gamma, IL-1beta, and TNF-alpha expression decreased, as well as no significant changes in Foxp3 expression were observed at day 14 post-operation. PMID: 27567557
- IL10 has a role in preventing -induced cell death in rat hippocampal cultures PMID: 28063948
- IL-10 592 polymorphism was associated with diabetic retinopathy susceptibility, suggesting that the gene polymorphism might be a risk factor for diabetic retinopathy PMID: 26492380
- Mesenchymal stromal cells inhibit Human antigen R (HuR) trascription, an enhancer of RENmRNA stability by IL10 release PMID: 26866372
- Mesenchymal stem cells decrease apoptosis and improve learning-memory function in hypoxic-ischemic brain damage rats by suppressing the TLR2/NFkappaB signaling pathway via a feedback mechanism that reduces IL-10 release. PMID: 26475712
- Green tea intake reduces expression of the pro-inflammatory cytokine TNF-alpha and the osteoclastogenic mediator RANKL to normal levels while increasing expression of the anti-inflammatory cytokine IL-10. PMID: 26270535
- IL-10 released from activated glial cells in the VLO can potentially attenuate allodynia while IL-1beta released from activated glial cells in the VLO can potentially maintain or facilitate allodynia PMID: 25617163
- The objectives of these studies were to investigate the responses of IL-10 receptors (IL-10Rs) and IL-10 signalling proteins (IL-10SPs) in hyperoxic foetal alveolar type II cells. PMID: 26059905
- Leydig cell-conditioned media dose-dependently stimulated expression of transcription factor Foxp3 and secretion of IL-10 in splenic CD4+ T cells, an effect abolished by addition of the anti-androgen flutamide. PMID: 25598450
- Exercise increased the amount of IL-1beta and IL-10 positive chondrocytes PMID: 25702530
- Study shows that, in addition to inducing persistent memory deficits, maternal deprivation increased the levels of the anti-inflammatory cytokine, IL-10, and of the pro-inflammatory cytokine, TNF-alpha, and decreased the levels of BDNF in the adulthood PMID: 25182413
- atropine in malathion intoxicated rats had no effect on suppression of the synthesis of proinflammatory cytokines TNF, IL-1g and IL-6 as well as the content of anti-inflammatory cytokines IL-10 and IL-13. PMID: 26591203
- Short-term but not long-term hypoglycaemia enhances plasma levels and hepatic expression of HSP72 in insulin-treated rats: an effect associated with increased IL-6 levels but not with IL-10 or TNF-alpha. PMID: 25096025
- the preserved ability of macrophages from aged AO rats to synthesize not only proinflammatory TNF-alpha, but also immunoregulatory IL-10 cytokine most likely contributes to their longer average life compared with DA rats PMID: 25009084
- The dysfunction of dendritic cells and the increase of IL-10-producing Breg and Foxp3(+) Treg might play important roles in hepatocellular carcinoma progression PMID: 25066760
- SOCS-3 was involved in cerebral vasospasm after subarachnoid hemorrhage via an IL-6- and IL-10-related mechanism. IL-10 levels increased during the first 6 h after SAH, after which this increase tapered off. PMID: 24463741
- results suggest that IL-10/HMOX1 signaling is involved in modulation of cochlear inflammation through inhibition of MCP-1/CCL2 regulation in SLFs PMID: 25780042
- The neuronal apoptosis rate was positively correlated with the levels of TNF-alpha and IL-6, and negatively correlated with IL-10 and GDNF. PMID: 24706318
- cells from long-lived rats exhibited a dramatic increase in IL-10 mRNA expression followed by diminished TNF-alpha and IL-6 mRNA expression, and comparable expression of IL-1beta mRNA relative to adult rats. PMID: 25081109
- Cerebral regulatory T cells restrain microglia/macrophage-mediated inflammatory responses via IL-10. PMID: 25329858
- Regulation of IL-10 by chondroitinase ABC promotes a distinct immune response following spinal cord injury PMID: 25471580
- We found cardiac and histological changes compatible with the inflammatory process triggered by acute pancreatitis with the promotion of local myocardial cytokine production. PMID: 24865534
- study provides novel evidence that IL-10 plays an up-regulatory role in the anti-hypertensive activity of CCL5 in SHR VSMCs PMID: 24656930
- The high expression in IL-1beta and IL-10 levels in small bowel and colon might explain the accelerated healing process in these wounds in comparison to skin and muscle tissues. PMID: 24114903
- Daily treatment with anti-IL10 antibody significantly increased paw edema. PMID: 23765634
- Prevention of acute liver allograft rejection by IL-10-engineered mesenchymal stem cells. PMID: 24527865
- Gemfibrozil plus metformin decrease MMP-9, increase IL-10 and adiponectin acting. PMID: 23111552
- Pro-inflammatory cytokines from area postrema and organum vasculosum laminae terminalis are modulated by IL-10 antibodies. PMID: 23388469
- GSK-3beta modulates inflammatory IL-10 levels released from cortical glia. PMID: 22796213
- These data in cardiomyocytes suggest that IL-10 induced anti-apoptotic signaling involves upregulation of TLR4 through MyD88 activation. PMID: 23141143
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亚细胞定位:Secreted.
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蛋白家族:IL-10 family
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