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  4. Rat IL-1 Receptor Like 1(IL1RL1)ELISA Kit

Rat IL-1 Receptor Like 1(IL1RL1)ELISA Kit

  • 中文名称：
    大鼠白介素1受体样1(IL1RL1)酶联免疫试剂盒
  • 货号：
    CSB-E14896r
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：

    This Rat IL1RL1 ELISA Kit was designed for the quantitative measurement of Rat IL1RL1 protein in serum, plasma, cell culture supernates, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 15.6 pg/mL-1000 pg/mL and the sensitivity is 3.9 pg/mL.

  • 别名：
    Il1rl1 ELISA Kit; Fit1 ELISA Kit; Interleukin-1 receptor-like 1 ELISA Kit; EC 3.2.2.6 ELISA Kit; Fit-1 ELISA Kit; Fos-responsive gene 1 protein ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Rattus norvegicus (Rat)
  • 样本类型：
    serum, plasma, cell culture supernates, tissue homogenates
  • 检测范围：
    15.6 pg/mL-1000 pg/mL
  • 灵敏度：
    3.9 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Others
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 线性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat IL1RL1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %86
    Range %80-92
    1:2Average %97
    Range %91-104
    1:4Average %96
    Range %91-101
    1:8Average %92
    Range %86-96
  • 回收率：
    The recovery of rat IL1RL1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9690-100
    EDTA plasma (n=4)9085-95
  • 标准曲线：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    10002.317 2.252 2.285 2.153
    5001.969 1.923 1.946 1.814
    2501.643 1.510 1.577 1.445
    1251.211 1.191 1.201 1.069
    62.50.832 0.784 0.808 0.676
    31.20.554 0.537 0.546 0.414
    15.60.325 0.305 0.315 0.183
    00.136 0.128 0.132 　
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.; Inhibits IL-33 signaling.
  • 基因功能参考文献：
    1. administration of sST2 significantly attenuated the severity of severe acute pancreatitis and associated cardiac damage, and the cardioprotective effect is associated with its anti-inflammatory action PMID: 29653119
    2. Study demonstrates that IL-33 and ST2 are highly expressed by various central nervous system (CNS) resident cells, and there was a change of the expression levels and patterns of both molecules in the CNS lesions of multiple sclerosis (MS)patients compared with healthy brain tissues. Furthermore, IL-33/ST2 signaling pathway may have its unique important function in the myelination process in the CNS compartment. PMID: 27455844
    3. A strong relationship of IL-33/ST2 with natriuretic peptides and classical inflammatory mediators was observed in cardiac tissue. Expression of sST2 in cardiac, adipose and liver tissue decreased in obese rats compared with controls, suggesting an involvement for IL-33/ST2 system in molecular mechanisms of obesity. PMID: 28274612
    4. these results demonstrated that ST2L translocation from the cytosol to the cell membranes of lung tissue and the down-expression of sST2 in both fractions can function as new biomarkers of (ventilator-induced lung injury. PMID: 25815839
    5. This is the first study demonstrating a deleterious role for sST2 in the vascular remodeling associated with obesity. PMID: 24265755
    6. Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling. PMID: 19919994

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.; [Isoform B]: Secreted.
  • 蛋白家族：
    Interleukin-1 receptor family
  • 组织特异性：
    Isoform A is detected in spleen, lung, bone marrow and lymh node. Isoform B is predominant in fibroblasts.
  • 数据库链接：